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You are here: Home / RESEARCH . . . . / Human Papillomavirus Research / Quantifying the possible cross-reactivity risk of an HPV16 vaccine

Quantifying the possible cross-reactivity risk of an HPV16 vaccine

May 7, 2011 By Norma

Darja Kanduc, Department of Biochemistry and Molecular Biology, University of Bari, Italy

Correspondence to: D. Kanduc, Department Biochemistry and Molecular Biology, University of Bari, Bari 70126 – Italy.

Telephone: 39 080 544 3321; Fax: 39 080 544 3321. Email: d.kanduc@biologia.uniba.it; dkanduc@gmail.com

(Received: March 18, 2009; accepted: May 5, 2009)

Background: The potential adverse events associated with vaccination for infectious diseases underscore the need for effective analysis and definition of possible  vaccine side effects. Using the HPV16 proteome as a model, we quantified the actual and theoretical risks of anti-HPV16 vaccination, and defined the potential disease spectrum derived from concomitant cross-reactions with the human organism.

Methods: We searched the primary sequence of the HPV16 proteome for heptamer aminoacid sequences shared with human proteins using the Protein International  Resource database.

Results: The human proteome contains 82 heptapeptides and two octapeptides found in HPV16. The viral matches are spread among proteins involved in fundamental processes, such as cell differentiation and growth and neurosensory regulation. The human proteins containing the HPV16-derived heptamers include cell adhesion molecules, leukocyte differentiation antigens, enzymes, proteins associated with spermatogenesis, transcription factors, and neuronal antigens. The number of viral matches and their locations make the occurrence of side autoimmune cross-reactions in the human host following HPV16-based vaccination almost unavoidable.

Conclusions: Any antigen-based vaccine needs to be carefully and thoroughly designed and critically screened for potential side effects by comparing sequence similarity at the molecular level.

Access the entire paper here.

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Filed Under: Human Papillomavirus Research Tagged With: autoimmune disorders, cross reactivity, HPV-16, human proteins

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HPV Vaccine VAERS Reports

Description 12/14/2019  TOTAL
Disabled 3,092
Deaths 523
Did Not Recover 13,072
Abnormal Smear 695
Cervical Cancer 186
Infertility 52
Life-threatening 1,001
Emergency Room 15,419
Hospitalized 6,448
Extended Hosp. Stay 304
Serious 9,497
Total Adverse Events 64,270

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