Authors: Alessandra Soriano, Gideon Nesher, Yehuda Shoenfeld Abstract Vaccinations have been used as an essential tool in the fight against infectious diseases and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants – ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by […]
Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations
Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations Matthew Mold,1 Emma Shardlow,1 and Christopher Exleya,1 Author information ► Article notes ► Copyright and License information ► Abstract Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) […]
Biopersistence and brain translocation of aluminum adjuvants of vaccines
Authors: Romain Kroum Gherardi*, Housam Eidi, Guillemette Crépeaux, François Jerome Authier and Josette Cadusseau Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic […]
Behavioral abnormalities in young female mice
Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. Authors: Inbar R1, Weiss R2, Tomljenovic L3, Arango MT4, Deri Y5, Shaw CA6, Chapman J7, Blank M5, Shoenfeld Y8 Abstract Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine […]
Vaccines, adjuvants and autoimmunity
Authors: Luísa Eça Guimarãesa, Britain Bakera, Carlo Perriconeb, Yehuda Shoenfelda,c Abstract Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards […]
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