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The First International HPV Vaccine Information Clearinghouse

Lessons learnt in Japan from adverse reactions to the HPV vaccine: a medical ethics perspective

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Authors: Hirokuni Beppu, Masumi Minaguchi, Kiyoshi Uchide, Kunihiko Kumamoto, Masato Sekiguchi, Yukari Yaju Abstract: The human papillomavirus (HPV) vaccine has been linked to a number of serious adverse reactions. The range of symptoms is diverse and they develop in a multi-layered manner over an extended period of time. The argument for the safety and effectiveness of […]

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The impact of HPV vaccination on future cervical screening: a simulation study of two birth cohorts in Denmark

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Authors:  Mie Sara Hestbech, Elsebeth Lynge, Jakob Kragstrup, Volkert Siersma, Miguel Vazquez-Prada Baillet, John Broderson Abstract: Objectives To explore the interplay between primary and secondary prevention of cervical cancer by estimating future screening outcomes in women offered human papillomavirus (HPV) vaccination when they were sexually naïve. Design Estimation of outcome of liquid-based cytology screening for a post-HPV vaccination […]

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Quadrivalent Human Papillomavirus Vaccine and the Young Ovary: Review of Safety Research Following Two Case Series of Premature Ovarian Insufficiency

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Author: Dr. D. Little Abstract: The quadrivalent virus-like particle vaccine against human papillomavirus (QHPV) is a population vaccine targeting peri-pubertal girls and boys. Focus on evaluation of adolescent ovarian safety arises from cases in primary care and published case series describing the development of menstrual dysfunction and idiopathic premature ovarian insufficiency (POI) following QHPV vaccination. […]

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Pharmaceutical Companies’ Role in State Vaccination Policymaking: The Case of Human Papillomavirus Vaccination

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Authors: Michelle M. Mello, JD, Ph.D., Sara Abiola, JD, Ph.D., and James Colgrove, PhD Abstract:   Objectives. We sought to investigate roles that Merck & Co Inc played in state human papillomavirus (HPV) immunization policymaking, to elicit key stakeholders’ perceptions of the appropriateness of these activities, and to explore implications for relationships between health policymakers and industry. […]

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Immune and Genetic Susceptibility in the Development of Cervical Cancer

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Authors:  Barbara Mora, Felipe M. Benavente,  Carmen G. Ili, and Pricilla Brebi Abstract:  Cervical cancer is the second most frequent cancer in women worldwide. Although 99.7% of cases are attributed to a previous infection by Human papillomavirus, a small percentage of the infected women progress to cervical cancer, suggesting the existence of different risk factors […]

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New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination

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Authors: Antonietta M. Gatti and Stefano Montanari Abstract Vaccines are being under investigation for the possible side effects they can cause. In order to supply new information, an electron-microscopy investigation method was applied to the study of vaccines, aimed at verifying the presence of solid contaminants by means of an Environmental Scanning Electron Microscope equipped with […]

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Predicting post-vaccination autoimmunity: Who might be at risk?

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Authors: Alessandra Soriano, Gideon Nesher, Yehuda Shoenfeld Abstract Vaccinations have been used as an essential tool in the fight against infectious diseases and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants – ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by […]

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Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase

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Authors: Rebecca E. Chandler, Kristina Juhlin, Jonas Fransson, Ola Caster, I. Ralph Edwards, G. Niklas Norén Abstract: Introduction A number of safety signals—complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)—have emerged with human papillomavirus (HPV) vaccines, which share a similar pattern of symptomatology. Previous signal evaluations and epidemiological studies have largely relied on traditional methodologies and signals have been […]

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Prophylactic HPV Vaccines: Current Knowledge of Impact on Gynecological Premalignancies

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Authors: Diane M. Harper and Karen B. Williams Abstract: Approaches for cervical cancer prevention are changing. Screening still remains the most effective method for cervical cancer prevention. Guidelines are moving to an older group of women to be screened less frequently with combinations of technologies that include biomarkers and cytology. HPV vaccination is an appropriate option for […]

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HPV: Non-sexual means of transmission

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Non sexual means Abstract Aim: There is strong evidence to suggest vertical and horizontal modes of transmission of human papilloma virus (HPV), an established etiologic agent of cervical cancer. Infants, children, and adults can acquire both high-risk and low-risk infections by birth or by close contact even though HPV is mainly transmitted sexually. A thorough […]

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination Highlights •32 patients with prolonged CNS symptoms after HPV vaccination were studied. •CSF levels of IL-4, IL-13, IL-17, IL-8 and MCP-1 were elevated. •CSF levels of PDGF-bb and IL-12 were decreased. •Antibodies to GluN2B-NT2, GluN2B-CT and GluN1-NT in CSF were increased. […]

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Transvaginal ultrasound probe contamination by the human papillomavirus in the emergency department.

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Is 'protecting' against 4 types of HPV enough to warrant the risks?

Transvaginal contamination Ma ST, et al. Emerg Med J. 2013. Abstract OBJECTIVE: To determine if human papillomavirus (HPV) DNA can be detected on the transvaginal sonography (TVS) probe in the emergency department (ED) and whether the current barrier method plus disinfection can prevent HPV contamination of the TVS probe. METHODS: This was a two-part cross-sectional […]

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Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature

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Somatoform and Sysautonomic Syndromes Authors: Beniamino Palmieri; Dimitri Poddighe; Maria Vadalà; Carmen Laurino; Carla Carnovale; Emilio Clementi Abstract: Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil® and Cervarix®. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection […]

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Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations

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Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations Matthew Mold,1 Emma Shardlow,1 and Christopher Exleya,1 Author information ► Article notes ► Copyright and License information ► Abstract Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) […]

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database Authors: David A. Geier, Mark R. Geier Abstract: Gardasil is a quadrivalent human papillomavirus (HPV4) vaccine that was approved for use by the US Food and Drug Administration in June 2006. HPV4 vaccine is routinely recommended […]

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Biopersistence and brain translocation of aluminum adjuvants of vaccines

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Authors: Romain Kroum Gherardi*, Housam Eidi, Guillemette Crépeaux, François Jerome Authier and Josette Cadusseau Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic […]

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Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

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Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]

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Behavioral abnormalities in young female mice

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Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. Authors: Inbar R1, Weiss R2, Tomljenovic L3, Arango MT4, Deri Y5, Shaw CA6, Chapman J7, Blank M5, Shoenfeld Y8 Abstract Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine […]

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Postural Orthostatic Tachycardia Syndrome (POTS) – A novel member of the autoimmune family

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Postural Orthostatic Tachycardia Syndrome (POTS) Authors: S Dahan, L Tomljenovic, Y Shoenfeld Abstract Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous disorder of the autonomic nervous system in which a change from the supine position to an upright position causes an abnormally large increase in heart rate or tachycardia (30 bpm within 10 min of standing or head-up […]

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Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010.

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Authors: Goldman GS1, Miller NZ. Abstract In this study, the Vaccine Adverse Event Reporting System (VAERS) database, 1990-2010, was investigated; cases that specified either hospitalization or death were identified among 38,801 reports of infants. Based on the types of vaccines reported, the actual number of vaccine doses administered, from 1 to 8, was summed for […]

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