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Prophylactic HPV Vaccines: Current Knowledge of Impact on Gynecological Premalignancies

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Authors: Diane M. Harper and Karen B. Williams Abstract: Approaches for cervical cancer prevention are changing. Screening still remains the most effective method for cervical cancer prevention. Guidelines are moving to an older group of women to be screened less frequently with combinations of technologies that include biomarkers and cytology. HPV vaccination is an appropriate option for […]

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HPV: Non-sexual means of transmission

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Non sexual means Abstract Aim: There is strong evidence to suggest vertical and horizontal modes of transmission of human papilloma virus (HPV), an established etiologic agent of cervical cancer. Infants, children, and adults can acquire both high-risk and low-risk infections by birth or by close contact even though HPV is mainly transmitted sexually. A thorough […]

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination Highlights •32 patients with prolonged CNS symptoms after HPV vaccination were studied. •CSF levels of IL-4, IL-13, IL-17, IL-8 and MCP-1 were elevated. •CSF levels of PDGF-bb and IL-12 were decreased. •Antibodies to GluN2B-NT2, GluN2B-CT and GluN1-NT in CSF were increased. […]

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Transvaginal ultrasound probe contamination by the human papillomavirus in the emergency department.

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Is 'protecting' against 4 types of HPV enough to warrant the risks?

Transvaginal contamination Ma ST, et al. Emerg Med J. 2013. Abstract OBJECTIVE: To determine if human papillomavirus (HPV) DNA can be detected on the transvaginal sonography (TVS) probe in the emergency department (ED) and whether the current barrier method plus disinfection can prevent HPV contamination of the TVS probe. METHODS: This was a two-part cross-sectional […]

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Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature

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Somatoform and Sysautonomic Syndromes Authors: Beniamino Palmieri; Dimitri Poddighe; Maria Vadalà; Carmen Laurino; Carla Carnovale; Emilio Clementi Abstract: Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil® and Cervarix®. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection […]

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Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations

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Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations Matthew Mold,1 Emma Shardlow,1 and Christopher Exleya,1 Author information ► Article notes ► Copyright and License information ► Abstract Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) […]

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database Authors: David A. Geier, Mark R. Geier Abstract: Gardasil is a quadrivalent human papillomavirus (HPV4) vaccine that was approved for use by the US Food and Drug Administration in June 2006. HPV4 vaccine is routinely recommended […]

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Biopersistence and brain translocation of aluminum adjuvants of vaccines

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Authors: Romain Kroum Gherardi*, Housam Eidi, Guillemette Crépeaux, François Jerome Authier and Josette Cadusseau Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic […]

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Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

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Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]

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Behavioral abnormalities in young female mice

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Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. Authors: Inbar R1, Weiss R2, Tomljenovic L3, Arango MT4, Deri Y5, Shaw CA6, Chapman J7, Blank M5, Shoenfeld Y8 Abstract Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine […]

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Postural Orthostatic Tachycardia Syndrome (POTS) – A novel member of the autoimmune family

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Postural Orthostatic Tachycardia Syndrome (POTS) Authors: S Dahan, L Tomljenovic, Y Shoenfeld Abstract Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous disorder of the autonomic nervous system in which a change from the supine position to an upright position causes an abnormally large increase in heart rate or tachycardia (30 bpm within 10 min of standing or head-up […]

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Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010.

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Authors: Goldman GS1, Miller NZ. Abstract In this study, the Vaccine Adverse Event Reporting System (VAERS) database, 1990-2010, was investigated; cases that specified either hospitalization or death were identified among 38,801 reports of infants. Based on the types of vaccines reported, the actual number of vaccine doses administered, from 1 to 8, was summed for […]

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Vaccines, adjuvants and autoimmunity

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Authors: Luísa Eça Guimarãesa, Britain Bakera, Carlo Perriconeb, Yehuda Shoenfelda,c  Abstract Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards […]

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HPV vaccination syndrome: A questionnaire-based study

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Authors: Manuel Martínez-Lavín, Laura-Aline Martínez-Martínez, Paola Reyes-Loyola Abstract Isolated cases and small series have described the development of complex regional pain syndrome, postural orthostatic tachycardia, and fibromyalgia after human papillomavirus (HPV) vaccination. These illnesses are difficult to diagnose and have overlapping clinical features. Small fiber neuropathy and dysautonomia may play a major role in the pathogenesis of these entities. We […]

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CNS demyelination and quadrivalent HPV vaccination

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Is 'protecting' against 4 types of HPV enough to warrant the risks?

CNS demyelination and quadrivalent HPV vaccination report: Authors: Sutton I1, Lahoria R, Tan I, Clouston P, Barnett M. Abstract Vaccination is generally considered safe in patients with multiple sclerosis (MS). We report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (HPV) vaccine, Gardasil. […]

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The safety of human papilloma virus blockers

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The safety of human papilloma virus blockers and the risk of triggering autoimmune diseases Authors: Baker B1, Eça Guimarães L, Tomljenovic L, Agmon-Levin N, Shoenfeld Y. Abstract INTRODUCTION: With the safety of human papilloma virus vaccine (HPVv) being questioned, this article aims to assess the risks and benefits of the commercially available HPVv. Within the last […]

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Prevalence of type-specific HPV among female university students from northern Brazil

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Authors: Rodrigo Covre Vieira1*, Jeniffer do Socorro Valente Monteiro2, Estéfane Primo Manso2, Maria Renata Mendonça dos Santos3, Mihoko Yamamoto Tsutsumi4, Edna Aoba Yassui Ishikawa1, Stephen Francis Ferrari5,Karla Valéria Batista Lima6 and Maísa Silva de Sousa1 Abstract Background Human papillomavirus (HPV) infection is associated with cervical cancer, the most frequent cancer in women from northern Brazil. Assessment […]

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Vitamin D Levels, Antibody Titers Produced in Response

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Do Vitamin D Levels Affect Antibody Titers Produced in Response to HPV Vaccine? Antibody Titers Produced in Response Authors: Zimmerman RK1, Lin CJ, Raviotta JM, Nowalk MP. Abstract In addition to its well-known effects on bone metabolism, vitamin D is an immunomodulating hormone. Serum vitamin D levels in males 18-25 years were measured at baseline, and HPV […]

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Vaccine adjuvants: Current state and future trends

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Future Trends Authors: Nikolai Petrovsky1 and Julio César Aguilar2 Abstract The problem with pure recombinant or synthetic antigens used in modern day vaccines is that they are generally far less immunogenic than older style live or killed whole organism vaccines. This has created a major need for improved and more powerful adjuvants for use in these vaccines. With […]

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Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

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Authors: Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]

[Continue reading...]

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