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Prophylactic HPV Vaccines: Current Knowledge of Impact on Gynecological Premalignancies

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Authors: Diane M. Harper and Karen B. Williams Abstract: Approaches for cervical cancer prevention are changing. Screening still remains the most effective method for cervical cancer prevention. Guidelines are moving to an older group of women to be screened less frequently with combinations of technologies that include biomarkers and cytology. HPV vaccination is an appropriate option for […]

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination Highlights •32 patients with prolonged CNS symptoms after HPV vaccination were studied. •CSF levels of IL-4, IL-13, IL-17, IL-8 and MCP-1 were elevated. •CSF levels of PDGF-bb and IL-12 were decreased. •Antibodies to GluN2B-NT2, GluN2B-CT and GluN1-NT in CSF were increased. […]

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Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature

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Somatoform and Sysautonomic Syndromes Authors: Beniamino Palmieri; Dimitri Poddighe; Maria Vadalà; Carmen Laurino; Carla Carnovale; Emilio Clementi Abstract: Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil® and Cervarix®. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection […]

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database Authors: David A. Geier, Mark R. Geier Abstract: Gardasil is a quadrivalent human papillomavirus (HPV4) vaccine that was approved for use by the US Food and Drug Administration in June 2006. HPV4 vaccine is routinely recommended […]

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Behavioral abnormalities in young female mice

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Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. Authors: Inbar R1, Weiss R2, Tomljenovic L3, Arango MT4, Deri Y5, Shaw CA6, Chapman J7, Blank M5, Shoenfeld Y8 Abstract Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine […]

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HPV vaccination syndrome: A questionnaire-based study

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Authors: Manuel Martínez-Lavín, Laura-Aline Martínez-Martínez, Paola Reyes-Loyola Abstract Isolated cases and small series have described the development of complex regional pain syndrome, postural orthostatic tachycardia, and fibromyalgia after human papillomavirus (HPV) vaccination. These illnesses are difficult to diagnose and have overlapping clinical features. Small fiber neuropathy and dysautonomia may play a major role in the pathogenesis of these entities. We […]

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CNS demyelination and quadrivalent HPV vaccination

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Is 'protecting' against 4 types of HPV enough to warrant the risks?

CNS demyelination and quadrivalent HPV vaccination report: Authors: Sutton I1, Lahoria R, Tan I, Clouston P, Barnett M. Abstract Vaccination is generally considered safe in patients with multiple sclerosis (MS). We report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (HPV) vaccine, Gardasil. […]

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The safety of human papilloma virus blockers

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The safety of human papilloma virus blockers and the risk of triggering autoimmune diseases Authors: Baker B1, Eça Guimarães L, Tomljenovic L, Agmon-Levin N, Shoenfeld Y. Abstract INTRODUCTION: With the safety of human papilloma virus vaccine (HPVv) being questioned, this article aims to assess the risks and benefits of the commercially available HPVv. Within the last […]

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Vitamin D Levels, Antibody Titers Produced in Response

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Do Vitamin D Levels Affect Antibody Titers Produced in Response to HPV Vaccine? Antibody Titers Produced in Response Authors: Zimmerman RK1, Lin CJ, Raviotta JM, Nowalk MP. Abstract In addition to its well-known effects on bone metabolism, vitamin D is an immunomodulating hormone. Serum vitamin D levels in males 18-25 years were measured at baseline, and HPV […]

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Reduction in HPV Prevalence— No Evidence to Support HPV Vaccination reduces HPV Prevalence

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Authors:  Jennifer A. Groner1, George D. Harris2 and Diane M. Harper3,4,5  TO THE EDITOR—The recent Centers for Disease Control and Prevention (CDC) study by Markowitz et al [1] provides limited and inconclusive data on 111 sexually active females between 14 and 19 years of age who received at least 1 dose of quadrivalent human papillomavirus vaccine (HPV4). The […]

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Review of Gardasil

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Review Authors: Diane M Harper,1,* Stephen L. Vierthaler,2 and Jennifer A Santee3 Abstract Human papillomavirus (HPV) is necessary for the development of cervical cancer. Cervical cancer is the second most common cancer in women worldwide but 80% occurs in developing countries, not countries with Pap screening programs. Pap screening programs in industrialized countries have reduced the […]

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Chronic Fatigue Syndrome / Myalgic Encephalomyelitis

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Is Chronic Fatigue Syndrome / Myalgic Encephalomyelitis a Relevant Diagnosis in Patients with Suspected Side Effects to Human Papilloma Virus Vaccine? Authors: Louise Brinth*, Kirsten Pors, Anna-Alexandra Grube Hoppe, Iman Badreldin and Jesper Mehlsen Frederiksberg Hospital, Denmark Abstract The quadrivalent human papilloma virus vaccine (Q-HPV-vaccine) was included into the Danish childhood vaccination program in 2009. […]

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Hypothesis: Human papillomavirus vaccination syndrome

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Hypothesis: Human papillomavirus vaccination syndrome – small fiber neuropathy and dysautonomia could be its underlying pathogenesis By Martinez-Lavin, M Abstract Vaccination has been one of the most effective public health measures in the history of medicine. However, seemingly inexplicit adverse reactions have been described after the injection of the newer vaccines vs. human papillomavirus (HPV). […]

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Autoimmune / auto inflammatory syndrome induced by (ASIA)

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Autoimmune / auto inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine Authors: Anaya JM1, Reyes B1, Perdomo-Arciniegas AM2, Camacho-Rodríguez B2, Rojas-Villarraga A1 Abstract This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were […]

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Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papilloma virus

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Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papilloma virus Authors: Louise S. Brinth, Kirsten Pors, Ann C. Theibel, Jesper Mehlsen Abstract Background Infections with human papilloma virus (HPV) can result in cervical, oropharyngeal, anal, and penile cancer and vaccination programs have been launched in many countries as a preventive measure. We report […]

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Population-level impact and herd effects following human papillomavirus vaccination  programmes:

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a systematic review and meta-analysis Authors: Mélanie Drolet, PhD†, Élodie Bénard, BSc, Marie-Claude Boily, PhD, Hammad Ali, PhD, Louise Baandrup, MD, Heidi Bauer, MD, Simon Beddows, PhD, Jacques Brisson, DSc, Julia M L Brotherton, BMed, Teresa Cummings, BA, Basil Donovan, MD, Christopher K Fairley, PhD, Elaine W Flagg, PhD, Anne M Johnson, MD, Jessica A Kahn, MD, Kimberley Kavanagh, PhD, Susanne K Kjaer, MD, Erich V Kliewer, PhD, Philippe Lemieux-Mellouki, MSc, Lauri Markowitz, MD, Aminata Mboup, […]

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Suspected side effects to the quadrivalent human papilloma vaccine, Gardasil

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Quadrivalent human papilloma vaccine By Louise Brinth1, 2, Ann Cathrine Theibel1, 2, Kirsten Pors1, & Jesper Mehlsen1, 2 1) Coordinating Research Centre/Syncope Unit, Grederiksberg Hospital; 2) Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Denmark Abstract Introduction: The quadrivalent vaccine that protects against human papilloma virus types 6, 11, 16 and 18 (Q-HPV vaccine, Gardasil) […]

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Early cervical myelitis after human papilloma virus vaccination

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Authors: Mireya Fernández-Fournier, MD, Javier Díaz de Terán, MD, Antonio Tallón Barranco, MD, PhD and Inmaculada Puertas, MD, PhD In 2006, an adjuvant vaccine against 4 human papillomavirus (HPV) types was licensed. By 2012, 45 countries had introduced HPV vaccination.1 HPV encompasses a group of more than 100 viruses, of which at least 13 are high-risk types, responsible for […]

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Quadrivalent HPV Vaccination and Risk of Multiple Sclerosis and Other Demyelinating Diseases of the Central Nervous System

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Multiple Sclerosis Scheller NM, Svanström H, Pasternak B, Arnheim-Dahlström L, Sundström K, Fink K, Hviid A Abstract IMPORTANCE: Case reports have suggested a link between human papillomavirus (HPV) vaccination and development of multiple sclerosis and other demyelinating diseases. OBJECTIVE: To investigate if quadrivalent HPV (qHPV) vaccination is associated with an increased risk of multiple sclerosis […]

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HPV Vaccine: Multiple Sclerosis and Diseases of the Central Nervous System

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Diseases of the Central Nervous System By Heather White A new 8-paged study published by combined efforts from research the departments of Denmark, and Sweden is now circulating the Internet.  This published peer-review was initiated based upon the descriptions of HPV vaccines associated with central nervous system diseases (Sutton et al., 2008; Chang et al., […]

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