Authors: Claire P. Reese, Petra Brhlikova, Allyson M. Pollock Abstract Summary We conducted a critical appraisal of published Phase 2 and 3 efficacy trials in relation to the prevention of cervical cancer in women. Our analysis shows the trials themselves generated significant uncertainties undermining claims of efficacy in these data. There were 12 randomised control […]
The impact of HPV vaccination on future cervical screening: a simulation study of two birth cohorts in Denmark
Authors: Mie Sara Hestbech, Elsebeth Lynge, Jakob Kragstrup, Volkert Siersma, Miguel Vazquez-Prada Baillet, John Broderson Abstract: Objectives To explore the interplay between primary and secondary prevention of cervical cancer by estimating future screening outcomes in women offered human papillomavirus (HPV) vaccination when they were sexually naïve. Design Estimation of outcome of liquid-based cytology screening for a post-HPV vaccination […]
Pharmaceutical Companies’ Role in State Vaccination Policymaking: The Case of Human Papillomavirus Vaccination
Authors: Michelle M. Mello, JD, Ph.D., Sara Abiola, JD, Ph.D., and James Colgrove, PhD Abstract: Objectives. We sought to investigate roles that Merck & Co Inc played in state human papillomavirus (HPV) immunization policymaking, to elicit key stakeholders’ perceptions of the appropriateness of these activities, and to explore implications for relationships between health policymakers and industry. […]
Prophylactic HPV Vaccines: Current Knowledge of Impact on Gynecological Premalignancies
Authors: Diane M. Harper and Karen B. Williams Abstract: Approaches for cervical cancer prevention are changing. Screening still remains the most effective method for cervical cancer prevention. Guidelines are moving to an older group of women to be screened less frequently with combinations of technologies that include biomarkers and cytology. HPV vaccination is an appropriate option for […]
Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination
Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination Highlights •32 patients with prolonged CNS symptoms after HPV vaccination were studied. •CSF levels of IL-4, IL-13, IL-17, IL-8 and MCP-1 were elevated. •CSF levels of PDGF-bb and IL-12 were decreased. •Antibodies to GluN2B-NT2, GluN2B-CT and GluN1-NT in CSF were increased. […]
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