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Quadrivalent Human Papillomavirus Vaccine and the Young Ovary: Review of Safety Research Following Two Case Series of Premature Ovarian Insufficiency

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Author: Dr. D. Little Abstract: The quadrivalent virus-like particle vaccine against human papillomavirus (QHPV) is a population vaccine targeting peri-pubertal girls and boys. Focus on evaluation of adolescent ovarian safety arises from cases in primary care and published case series describing the development of menstrual dysfunction and idiopathic premature ovarian insufficiency (POI) following QHPV vaccination. […]

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Predicting post-vaccination autoimmunity: Who might be at risk?

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Authors: Alessandra Soriano, Gideon Nesher, Yehuda Shoenfeld Abstract Vaccinations have been used as an essential tool in the fight against infectious diseases and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants – ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by […]

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Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase

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Authors: Rebecca E. Chandler, Kristina Juhlin, Jonas Fransson, Ola Caster, I. Ralph Edwards, G. Niklas Norén Abstract: Introduction A number of safety signals—complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)—have emerged with human papillomavirus (HPV) vaccines, which share a similar pattern of symptomatology. Previous signal evaluations and epidemiological studies have largely relied on traditional methodologies and signals have been […]

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination

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Immunological studies of cerebrospinal fluid from patients with CNS symptoms after human papillomavirus vaccination Highlights •32 patients with prolonged CNS symptoms after HPV vaccination were studied. •CSF levels of IL-4, IL-13, IL-17, IL-8 and MCP-1 were elevated. •CSF levels of PDGF-bb and IL-12 were decreased. •Antibodies to GluN2B-NT2, GluN2B-CT and GluN1-NT in CSF were increased. […]

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Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature

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Somatoform and Sysautonomic Syndromes Authors: Beniamino Palmieri; Dimitri Poddighe; Maria Vadalà; Carmen Laurino; Carla Carnovale; Emilio Clementi Abstract: Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil® and Cervarix®. Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection […]

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database

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Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case–control assessment of the vaccine adverse event reporting system (VAERS) database Authors: David A. Geier, Mark R. Geier Abstract: Gardasil is a quadrivalent human papillomavirus (HPV4) vaccine that was approved for use by the US Food and Drug Administration in June 2006. HPV4 vaccine is routinely recommended […]

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Postural Orthostatic Tachycardia Syndrome (POTS) – A novel member of the autoimmune family

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Postural Orthostatic Tachycardia Syndrome (POTS) Authors: S Dahan, L Tomljenovic, Y Shoenfeld Abstract Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous disorder of the autonomic nervous system in which a change from the supine position to an upright position causes an abnormally large increase in heart rate or tachycardia (30 bpm within 10 min of standing or head-up […]

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Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010.

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Authors: Goldman GS1, Miller NZ. Abstract In this study, the Vaccine Adverse Event Reporting System (VAERS) database, 1990-2010, was investigated; cases that specified either hospitalization or death were identified among 38,801 reports of infants. Based on the types of vaccines reported, the actual number of vaccine doses administered, from 1 to 8, was summed for […]

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Vaccines, adjuvants and autoimmunity

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Authors: Luísa Eça Guimarãesa, Britain Bakera, Carlo Perriconeb, Yehuda Shoenfelda,c  Abstract Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards […]

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HPV vaccination syndrome: A questionnaire-based study

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Authors: Manuel Martínez-Lavín, Laura-Aline Martínez-Martínez, Paola Reyes-Loyola Abstract Isolated cases and small series have described the development of complex regional pain syndrome, postural orthostatic tachycardia, and fibromyalgia after human papillomavirus (HPV) vaccination. These illnesses are difficult to diagnose and have overlapping clinical features. Small fiber neuropathy and dysautonomia may play a major role in the pathogenesis of these entities. We […]

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The safety of human papilloma virus blockers

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The safety of human papilloma virus blockers and the risk of triggering autoimmune diseases Authors: Baker B1, Eça Guimarães L, Tomljenovic L, Agmon-Levin N, Shoenfeld Y. Abstract INTRODUCTION: With the safety of human papilloma virus vaccine (HPVv) being questioned, this article aims to assess the risks and benefits of the commercially available HPVv. Within the last […]

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Chronic Fatigue Syndrome / Myalgic Encephalomyelitis

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Is Chronic Fatigue Syndrome / Myalgic Encephalomyelitis a Relevant Diagnosis in Patients with Suspected Side Effects to Human Papilloma Virus Vaccine? Authors: Louise Brinth*, Kirsten Pors, Anna-Alexandra Grube Hoppe, Iman Badreldin and Jesper Mehlsen Frederiksberg Hospital, Denmark Abstract The quadrivalent human papilloma virus vaccine (Q-HPV-vaccine) was included into the Danish childhood vaccination program in 2009. […]

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Etiology of autism spectrum disorders: Genes, environment, or both?

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Autism Authors: C Shaw, S Sheth, D Li, L Tomljenovic Abstract Introduction Thus far, most of the research on both neurodevelopmental and neurodegenerative disorders has been focused on finding the presumed underlying genetic causes, while much less emphasis has been put on potential environmental factors. While some forms of autism are clearly genetic, the fact remains […]

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Autoimmune / auto inflammatory syndrome induced by (ASIA)

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Autoimmune / auto inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine Authors: Anaya JM1, Reyes B1, Perdomo-Arciniegas AM2, Camacho-Rodríguez B2, Rojas-Villarraga A1 Abstract This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were […]

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Preliminary development of treatment for HPV vaccine injured girls

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Injured Girls By Stig Gerdes, MD Dear reader, Here is a preliminary statement of my diagnosis and treatment of 13 very, very sick women, of whom 11 are HPV vaccine injured and 2 are affected by ME (myalgic encephalomyelitis). As seen, the treatment has an effect and I have no doubt that it is curative […]

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Human adjuvant related syndrome or autoimmune/inflammatory syndrome induced by adjuvants

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Human adjuvant related syndrome or autoimmune/inflammatory syndrome induced by adjuvants Adjuvant Related Syndrome. Where have we come from? Where are we going? A proposal for new diagnostic criteria. By Alijotas-Reig J. Lupus. 2015. Abstract In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this […]

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Suspected side effects to the quadrivalent human papilloma vaccine, Gardasil

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Quadrivalent human papilloma vaccine By Louise Brinth1, 2, Ann Cathrine Theibel1, 2, Kirsten Pors1, & Jesper Mehlsen1, 2 1) Coordinating Research Centre/Syncope Unit, Grederiksberg Hospital; 2) Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Denmark Abstract Introduction: The quadrivalent vaccine that protects against human papilloma virus types 6, 11, 16 and 18 (Q-HPV vaccine, Gardasil) […]

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HPV Vaccine: Multiple Sclerosis and Diseases of the Central Nervous System

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Diseases of the Central Nervous System By Heather White A new 8-paged study published by combined efforts from research the departments of Denmark, and Sweden is now circulating the Internet.  This published peer-review was initiated based upon the descriptions of HPV vaccines associated with central nervous system diseases (Sutton et al., 2008; Chang et al., […]

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Fibromyalgia Like Illness in 2 Girls After Human Papillomavirus Vaccination

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Fibromyalgia Like Illness Fibromyalgia Like Illness after HPV Vaccination Author: Martínez-Lavín, Manuel MD Journal of Clinical Rheumatology  To the Editor: Chronic arthralgias are recognized human papillomavirus (HPV) vaccine side effects. The United Kingdom National Health Service Web page contains the following statement: “More than 1 in 100 people who have the Gardasil HPV vaccine experience fever, […]

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A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events

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Autoimmune Adverse Events Geier DA1, Geier MR. Abstract GARDASIL (Merck & Co., Inc., Whitehouse Station, NJ, USA) is a quadrivalent human papillomavirus (HPV4) vaccine. An epidemiological study was undertaken to evaluate concerns about the potential for HPV4 vaccination to induce serious autoimmune adverse events (SAAEs). The vaccine adverse event reporting system (VAERS) database was examined […]

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