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You are here: Home / NEWS . . . . . . . . / Science & Medicine / Cancer / Comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model

Comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model

November 18, 2011 By Jonathan Leave a Comment

BMJ

BMJ 2011; 343 doi: 10.1136/bmj.d5775 (Published 27 September 2011)

Cite this as: BMJ 2011;343:bmj.d5775
Accepted 26 August 2011

Abstract

Objectives To compare the effect and cost effectiveness of bivalent and quadrivalent human papillomavirus (HPV) vaccination, taking into account differences in licensure indications, protection against non-vaccine type disease, protection against disease related to HPV types 6 and 11, and reported long term immunogenicity.

Design A model of HPV transmission and disease previously used to inform UK vaccination policy, updated with recent evidence and expanded to include scenarios where the two vaccines differ in duration of protection, cross protection, and end points prevented.

Setting United Kingdom.

Population Males and females aged 12–75 years.

Main outcome measure Incremental cost effectiveness ratios for both vaccines and additional cost per dose for the quadrivalent vaccine to be equally cost effective as the bivalent vaccine.

Results The bivalent vaccine needs to be cheaper than the quadrivalent vaccine to be equally cost effective, mainly because of its lack of protection against anogenital warts. The price difference per dose ranges from a median of £19 (interquartile range £12–£27) to £35 (£27–£44) across scenarios about vaccine duration, cross protection, and end points prevented (assuming one quality adjusted life year (QALY) is valued at £30 000 and both vaccines can prevent all types of HPV related cancers).

Conclusions The quadrivalent vaccine may have an advantage over the bivalent vaccine in reducing healthcare costs and QALYs lost. The bivalent vaccine may have an advantage in preventing death due to cancer. However, considerable uncertainty remains about the differential benefit of the two vaccines.

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Filed Under: Cancer, HPV, HPV Science, United Kingdom Tagged With: adverse events, cervical cancer vaccine, HPV, HPV VACCINES, Vaccine Adverse Reactions

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HPV Vaccine VAERS Reports

Description 12/14/2019  TOTAL
Disabled 3,092
Deaths 523
Did Not Recover 13,072
Abnormal Smear 695
Cervical Cancer 186
Infertility 52
Life-threatening 1,001
Emergency Room 15,419
Hospitalized 6,448
Extended Hosp. Stay 304
Serious 9,497
Total Adverse Events 64,270

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