ISIS Report 07/01/09
Widespread releases of hazardous transgenes and vaccines have the potential to create viruses more deadly than the ones the vaccines protect against.
Human papilloma virus (HPV) vaccines are already commercialised and promoted worldwide in a bid to protect young girls and women from cervical cancer [1, 2] (Recombinant Cervical Cancer Vaccines, SiS 29; The HPV Vaccine Controversy, SiS 41), while there is still major uncertainty over their efficacy and safety, especially in the long term. One obstacle to the adoption of the vaccines by developing countries is that the two available are very costly. There appears to have been a rush to create cheap oral HPV vaccines in transgenic plants, microbes and viruses that do not require refrigeration and can be distributed relatively inexpensively, but would involve widespread releases of hazardous transgenes and products into the open environment. Some of these are near commercialization, and regulators must be warned against the approval of such production methods unless and until strict containment and safeguards are put in place.
HPV Vaccines in Crop Plants
The main concern over the vaccines produced in crop plants is that transgenes from tests sites or production farms can readily spread by pollen or by mechanical dispersal of seeds. Debris from transgenic crops can also spread transgenes and vaccine proteins through contaminating surface and groundwater. Debris in the form of dust in the air can impact on the respiratory mucosa directly, with the potential of triggering acute and delayed immune reactions in humans and animals exposed. HPV vaccines have already been associated with various adverse acute immune reactions some of which resulted in death . People subject to persistent exposure to the crop vaccine are likely to develop oral tolerance rendering them susceptible to virus infection  (Pharm Crops for Vaccines and Therapeutic Antibodies, SiS 24)..