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You are here: Home / NEWS . . . . . . . . / Vaccine Adverse Events / Endocrine System / Cervical Cancer HPV / Detection of Human Papillomavirus Types 16 and 18 mRNA in Peripheral Blood of Advanced Cervical Cancer Patients and Its Association With Prognosis

Detection of Human Papillomavirus Types 16 and 18 mRNA in Peripheral Blood of Advanced Cervical Cancer Patients and Its Association With Prognosis

August 28, 2010 By Jonathan Leave a Comment

Journal of Clinical Oncology, Vol 17, Issue 5 (May), 1999: 1391
© 1999 American Society for Clinical Oncology
Chih-Jen Tseng, Chia C. Pao, Jen-Daw Lin, Yung-Kuei Soong, Ji-Hong Hong, Swei Hsueh
From the Departments of Obstetrics and Gynecology, Radiation Oncology, and Pathology, Chang Gung Memorial Hospital, and Department of Biochemistry, Chang Gung University College of Medicine, Taipei, Taiwan.

Address reprint requests to Chih-Jen Tseng, MD, Department of Gynecology and Obstetrics, Chang Gung Memorial Hospital, No. 5, Fu-Shing St, Kweishan 333, Taoyuan, Taiwan; email jantseng@ ms1.hinet.net.

ABSTRACT

PURPOSE: To evaluate the feasibility of detecting human papillomavirus E6 (HPVE6) gene mRNA in the peripheral blood of patients with locally advanced cervical cancer, and the relationship of the circulating HPV viral–specific mRNA with clinicopathologic factors and prognosis of locally advanced cervical cancer.

PATIENTS AND METHODS: The presence of types 16 and 18 HPVE6 gene mRNA was determined by reverse transcription followed by nested polymerase chain reaction. Thirty-five patients with locally advanced cervical cancer who were positive for HPV type 16 or 18 DNA were included in the study. All patients received external-beam radiation therapy followed by intracavitary brachytherapy.

RESULTS: Eighteen (51.4%) of 35 HPV DNA–positive cervical cancer patients had HPV-specific mRNA in their peripheral blood cells, compared with none of 17 HPV DNA–negative cervical cancer patients and none of 12 control volunteers. The presence of HPVE6 gene mRNA in peripheral blood was associated with bulky tumor volume (> 4 cm) and pelvic lymph node metastasis (tumor volume, P = .03; lymph node status, P = .03). After a median follow-up of 22 months, patients who were positive for peripheral-blood HPVE6 gene mRNA had a significantly higher risk of recurrence than those who were negative (10 of 18 v three of 17, P = .02; mean recurrent time, 20.7 months v 12.6 months, P = .02). There was also a statistically significant association of peripheral-blood HPVE6 gene mRNA positivity with distant metastasis (eight of 18 v one of 17; P = .01).

CONCLUSION: Results of this study seem to suggest that the presence of HPVE6 gene mRNA in peripheral blood may provide an early marker that identifies patients who are at risk for metastasis.

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Filed Under: Cervical Cancer HPV Tagged With: Cervical Cancer HPV

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Description 12/14/2019  TOTAL
Disabled 3,092
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