- Report By: Simon Paget – Paediatric Registrar
- Search checked by Ian Maconichie –
- Institution: Queen Elizabeth Hospital Woolwich
- Date Submitted: 9th July 2008
- Last Modified: 1st August 2008
- Status:
Blue (submitted but not checked)
Three Part Question
In [premature neonates] does [primary immunisation] result in elevation of [C-Reactive Protein levels]?
Clinical Scenario
A premature neonate has received their first set of immunisations. Routine blood investigations two days following reveal a raised C-Reactive Protein (CRP). Other than a low-grade fever, the infant has been otherwise well. Can this raised CRP be explained by preceding immunisation or is it a sign of an evolving sepsis illness?
Search Strategy
Medline: 1950 to July 2008 and Embase: 1980 to 2008 week 30, both using the OVID interface.
[Immunisation OR Vaccination] AND [C-Reactive Protein OR CRP]
Limits: Human; Infant: Birth to 23 months (Medline); Birth to 1 year (Embase)
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