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You are here: Home / NEWS . . . . . . . . / Vaccine Adverse Events / Vaccine Associated Disorders / Autism / Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair

Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair

October 21, 2010 By Jonathan 1 Comment

Zhongqi-Phyllis Wua, b, 1, Lorraine Washburna, 1, Tina V. Bilousovaa, Maia Boudzinskaiaa, Nathalie Escande-Beillarda, Jyes Querubina, Hoa Danga, Cui-Wei Xiec, Jide Tiana and Daniel L. Kaufmana, b, ,

a Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90024, USA

b Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, 90024, USA

c Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, 90024, USA

Journal of Immunology

Received 24 August 2010;
accepted 15 September 2010.
Available online 14 October 2010.

Abstract

Mice deficient in classical major histocompatibility complex class I (MHCI) have aberrations in neurodevelopment. The consequences of upregulated neuronal MHCI expression have not been examined. We found that transgenic C57Bl/6 mice that are engineered to express higher levels of self-Db on their CNS neurons have alterations in their hippocampal morphology and retinogeniculate projections, as well as impaired neurorepair responses. Thus, enhanced neuronal classical MHCI expression can lead to aberrations in neural circuitry and neurorepair. These findings complement a growing body of knowledge concerning the neurobiological activities of MHCI and may have potential clinical relevance.

Keywords: Major histocompatibility complex class I (MHCI); Neurodevelopment; Neurorepair; ß2M; MHCI-deficient

Article Outline

1.

Introduction
2.

Materials and methods
2.1. Animals
2.2. Anterograde tracing
2.3. Electrophysiology
2.4. Presynaptic marker density
2.5. Hippocampal layer width measurements and cell counts
2.6. Perforant path lesioning
2.7. AChE histochemistry
2.8. Spontaneous alternation behavior
3.

Results
3.1. Alterations in retinogeniculate projections and dLGN structure in NSE-Db mice
3.2. Normal basal synaptic transmission and LTP induction in the CA1 region of NSE-Db mice
3.3. Reduced synaptophysin and GAP-43 immunoreactivity in the NSE-Db hippocampus
3.4. Reduced number of pyramidal neurons in the CA1 region of NSE-Db mouse hippocampus
3.5. Deficient neurorepair responses in NSE-Db mice
4.

Discussion
Acknowledgements
References
Read Full Study…

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Filed Under: Autism, MMR, Nervous System, Rotavirus Vaccines, Vaccine Adverse Events Tagged With: autism, cervarix, Cervical Cancer HPV, Gardasil/Silgard, H1N1 vaccine, HPV VACCINES, immunizations, Vaccine Adverse Reactions

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