Guillain-Barré syndrome after Gardasil vaccination: data from Vaccine Adverse Event Reporting System 2006-2009
Guillain-Barré syndrome after Gardasil: Souayah N1, Michas-Martin PA, Nasar A, Krivitskaya N, Yacoub HA, Khan H, Qureshi AI.
Using data from Vaccine Adverse Event Reporting System, we identified 69 reports of Guillain-Barré Syndrome (GBS) after Gardasil vaccination that occurred in the United States between 2006 and 2009. The onset of symptoms was within 6 weeks after vaccination in 70% of the patients in whom the date of vaccination was known. The estimated weekly reporting rate of post-Gardasil GBS within the first 6 weeks (6.6 per 10,000,000) was higher than that of the general population, and higher than post-Menactra and post-influenza vaccinations. Further prospective active surveillance for accurate ascertainment and identification of high-risk groups of GBS after Gardasil vaccination is warranted.
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The study shows that there is a higher rate of GBS after vaccination with Gardasil than that of the general population.
In reality, the actual impact of the Gardasil vaccinations may be even higher. The reason is that there are also Gardasil vaccinated amongst the general population.
If the rate of GBS amongst Gardasil vaccinated was compared with the rate of a group of unvaccinated, the difference between these two groups would probably be even higher.