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You are here: Home / NEWS . . . . . . . . / Science & Medicine / Cancer / Cervical Cancer / From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice

From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice

October 18, 2014 By admin Leave a Comment

Cervical Cancer Prevention

Sin Hang Lee, Jessica S. Vigliotti, Veronica S. Vigliotti and William Jones

Abstract:

The newly gained knowledge of the viral etiology in cervical carcinogenesis has prompted industrial interests in developing virology-based tools for cervical cancer prevention. Due to the long incubation period from viral infection to developing an invasive cancer, a process whose outcome is influenced by numerous life-style and genetic factors, the true efficacy of the genotype-specific human papillomavirus (HPV) vaccines in cervical cancer prevention cannot be determined for another 30 years. Most HPV DNA test kits designed to replace the traditional Papanicolaou (Pap) smears for precancer detection lack the analytical sensitivity and specificity to comprehensively detect all potentially carcinogenic HPVs and to perform reliable genotyping. The authors implemented the classic nested PCR and Sanger DNA-sequencing technology for routine HPV testing. The results showed a true negative HPV PCR invariably indicates the absence of precancerous cells in the cytology samples. However, 80.5% of single positive HPV-16 tests and 97.3% of single positive HPV-18 tests were associated with a negative or a largely self-reversible Pap cytology. Routine sensitive and reliable HPV type-specific or perhaps even variant-specific methods are needed to address the issues of persistence of HPV infection if a virology-based primary cervical screen is used to replace the Pap cytology screening paradigm.

Keywords: reliable HPV genotyping; DNA sequencing; persistent HPV infections; cervical screen; cervical cancer; pap smears; cervical cytology;cervical cancer prevention
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Access the complete paper here.

 

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Filed Under: Cervical Cancer, HPV Testing, Human Papillomavirus Research, United States, Vaccine Related Research Tagged With: cervical cancer prevention, reliable HPV genotyping

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Description 12/14/2019  TOTAL
Disabled 3,092
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Cervical Cancer 186
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Total Adverse Events 64,270

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