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You are here: Home / NEWS . . . . . . . . / Vaccines / HPV / Cervarix / India: HPV vaccines Gardasil and Cervarix make it to the Supreme Court

India: HPV vaccines Gardasil and Cervarix make it to the Supreme Court

January 16, 2013 By admin 14 Comments

The government of India has been ordered by their Supreme Court to file an answer to allegations brought forth by petitioners representing Gramya Resource Centre for Women from Andhra Pradesh on January 7, 2013. The suit challenges the licensing of Gardasil and Cervarix for use in the private sector of India. Details of the pending case are outlined below in a press release published by petitioners Kalpana Mehta, Nalini Bhanot and V. Rukmini Rao. 

Press Release January 7, 2013:

Supreme Court admits writ petition against licensing and trials with “Cervical Cancer” vaccines implicating the Drugs Controller of India, PATH, ICMR and others ordering Government of India to immediately  respond

HPV Vaccines versus Public Health and Safety
HPV Vaccines versus Public Health and Safety

Gardasil and Cervarix are two unproven and hazardous HPV vaccines purported to prevent cervical cancer, marketed in India by MSD Pharmaceuticals Pvt. Ltd. (subsidiary of Merck) and GlaxoSmithKline Ltd. The petition challenging their licensing for use in the private sector and attempts to introduce them in the public sector has been filed by Kalpana Mehta, Nalini Bhanot and V. Rukmini Rao representing (Gramya Resource Centre for Women from Andhra Pradesh). The petition implicates the Drugs Controller for having licensed the vaccines without adequate research on safety and efficacy;  the Health Ministry for not carrying out an enquiry into licensing of these vaccines as ordered by the Parliamentary Standing Committee on Health and Family Welfare in April 2010 nor taking any action on the report of the enquiry committee set up by itself despite all irregularities of PATH project being confirmed. Rather than looking at safety and efficacy of these vaccines in India, this project was meant to influence the government to adopt these vaccines for introduction in the public sector.

The petitioners are represented by the well known public interest senior advocate Colin Gonsalves of Human Rights Law Network who presented the case before the Supreme Court on January 7, 2013. The Supreme Court admitted the case and has asked the Government of India to immediately file its reply in the matter.

PATH had initiated a project for the introduction of the two vaccines in India by signing an MoU with ICMR even before they were licensed by the Drugs Controller of India. This project was funded by Bill and Melinda Gates Foundation (BMGF) who had substantial stakes in Merck that produced the vaccine and hence there was a direct conflict of interest.  PATH was helped by ICMR in carrying out large scale trials in the states of Andhra Pradesh and Gujarat unethically and without regard for health of poor tribal girls. The unethical nature of the study and deaths of girls became the subject of Governmental enquiry in 2010 when the matter was repeatedly raised by activists. This enquiry concluded that there were many gross violations in the project with respect to procedures for taking informed consent, inadequate health  facilities for dealing with adverse events and medical emergencies. Yet after two years of the enquiry the government had not even initiated any action to redress the situation and to punish PATH and ICMR as admitted  by Ghulam Nabi Azad before the Indian Parliament in December 2011.

The petitioners are health activists who have been raising the issue with the Health Ministry, the Drugs Controller,  National Commission for the Protection of Child Rights and other authorities including the government of Andhra Pradesh and have not made any headway. Hence a petition was filed under article 32 of the Constitution by them..

Hazards of the vaccines and unproven benefits :

The vaccines are genetically engineered and their hazards are unknown even to the scientific communities. Though r-DNA has been detected in Gardasil in samples from many countries including India, in their application for licensing MSD pharmaceuticals claimed that there was no hazard because there was no r-DNA. GlaxoSmithKline uses a novel technique for producing Cervarix which involves the use of insect cells. Their product information admitted to their vaccine containing insect cells and proteins only in July 2011 though the vaccine was already in use since 2007. These residues or adventitious agents enter the blood stream when the vaccine is injected and are acknowledged to have the capacity to cause infections, tumours and cancer. What is noteworthy is that neither of these vaccines has been studied to determine their potential to cause cancer. In addition, the Drugs Controller has not even set standards of acceptable limits for such contamination in vaccines on the basis of which he could have found them safe for licensing.

Though both the vaccines are claimed to prevent cervical cancer, the truth is that cervical cancer takes twenty or more years to develop and the vaccines have just not been around that long to prove their efficacy in preventing cancer. But what is known with certainty is that if these vaccines are given to women who already are infected with the virus then they do raise the incidence of cervical cancer among those women.

Gardasil was first licensed in the USA in June 2006. This licensing was done on fast track with numerous conflicts of interests not only on the review board but also in that that the vaccine patent was held in PPP and the FDA itself as a part of the health department would benefit from the sales.

Licensing issues:

Both vaccines were licensed for use among girls and women in India on the basis of very small studies that flouted even the liberalized Indian law. This law allows easy access to the Indian market for drugs and vaccines produced by multi-national companies once they are approved in the home country. In 2005 this law also made it possible for multi-national companies to hold trials for unapproved drugs in India simultaneous to international trials.

Targeting adolescents:

These vaccines are supposed to work best when administered to girls in the age group of 9-14, before sexual debut. In the case of Cervarix GlaxoSmithKline did a trial with just 176 adult women and was granted a license for an age group of 10-45 year old women. This trial just looked at anti-body levels achieved and immediate side effects. No trial was done among Indian girls.

In the case of Gardasil, Merck through its subsidiary MSD signed an MOU with ICMR in 2005 but did not proceed with the studies that were envisaged involving thousands of women. But once it was licensed in the USA it did a  speedy trial on its own with only 110 Indian girls 10-14 year old again to see immediate immune response. But it got a license by the DCGI to administer it to women from 9-26 years old though not a single adult woman had undergone a trial. According to the Indian law a trial on adults has to precede a trial among children and it was these violations that had been brought to the notice of the Parliamentary Committee that had asked for a proper enquiry into licensing.

Violations in PATH project:

PATH on its own had decided to do studies with the HPV vaccine in four countries and India was one of them. The Indian market is substantial if a vaccine is accepted in the immunization programme. There is documentary evidence that though PATH is an NGO in this case it had entered into business agreement with Merck so that Merck had a ready market for the vaccine in the resource poor countries. In fact PATH got funding from BMGF in the very month that Gardasil was licensed in the USA. It signed an MOU with ICMR for this purpose. ICMR played along though it was clear that the vaccine was too expensive for India to afford. For each girl vaccinated the country would need to spend Rs 10,000 for three shots. The vaccines were marketed by hyping the risk of cervical cancer. Yet the fruits of this approach were not going to be reaped for 30-40 years or when the ten year olds crossed the age of forty – the age group when women are susceptible to cervical cancer. ICMR went ahead though it knew that the country is unable to meet the present needs of medicines to meet the current problems of the population like T.B. and malaria and could ill afford to spend money for these uncertain products. Further through its cancer registries it was also aware that the incidence of cervical cancer was declining and it was not a major health problem of the country.

PATH project was carried out in total disregard to scientific approach. It made false claims about the safety of vaccines and their efficacy. When the project took off there was no data to figure out the need for boosters, how the malnourished girls of India would respond to the vaccine that had so far only been administered to a healthy population. Yet a large number of girls in A.P. and Gujarat were told all kinds of lies and administered a vaccine that had serious side effects including death. When four girls died in Andhra Pradesh women’s groups raised a hue and cry in 2010 and the government ordered an enquiry. The Government of AP, of Gujarat and PATH made depositions and provided data. The Enquiry Committee found that records of even informed consent had been fudged. The girls were not asked for their assent even though the law provides for such assent to be taken in writing. Further no arrangements were made for providing medical care to them if they suffered serious side effects.

Thus the rights of all 24,000 girls who were recruited by PATH in these trials were flouted as they were given the vaccine without a chance to make free informed choice. This assertion of women’s groups was confirmed by the enquiry. However, the Enquiry Committee had no legal expert and could not determine the liability of PATH towards the girls who were duped or forced into participation in PATH trial, those who died during the trial and those who would have suffered serious side effects.

PATH did everything to prevent the problems of the study from becoming common knowledge and sat on data on deaths despite women’s groups making a hue and cry about it at a public meeting organized by them in December 2009. The petitioners have pointed out that the data on death during the project is incomplete, illogical and full of discrepancies yet the deaths were called as being unrelated to vaccine administration. Side effects reported by the Study were very rare and this was also brought out in the Enquiry. Yet there is no provision of continuing health care of these rural girls. Extrapolating from trial data of the two companies the petitioners have estimated that there are at least 1,200 girls in the two states have suffered from serious side effects or have developed auto-immune disorders who need continuing medical care and treatment.

These questions have been put before the Supreme Court with the hope that prompt justice and care would be provided to girls who are suffering as a consequence of an ill designed trial carried out by PATH with the active support of ICMR and the two state governments. By those very governments who are constitutionally bound to protect their life and health. Given the serious violations indulged by PATH, the petitioners have asked that PATH be blacklisted and no other foreign agency be allowed to have field presence.

The petitioners have also asked for the licences of the two products to be suspended and the vaccines recalled as there has been no scientific basis to allow their administration to girls in the private market either. The two companies have also flouted Indian law with impunity and have not done the post marketing studies ordered by the Drugs Controller at the time of licensing. They have not up dated their product information and hence the Indian medical consumer continues to be in the dark about hazards of these vaccines that contain insect cells and r-DNA. MSD Pharmaceuticals went a step further and got the eligible age group extended to 45 year old women in India though this was denied in the U.S.A. thrice.

Kalpana Mehta kalpanaindu@hotmail.com Tel: 9425056985
Nalini Bhanot nalinibeez@gmail.com Tel:9899905851
V. Rukmini Rao vrukminirao@yahoo.com Tel: 9440860271

 

Read additional information via The Hindu here.

Related article by Christina England here.

Coverage by The Economic Times of India here.

Coverage by The Hindu Business Line here.

 

 

 

Related

Filed Under: Cervarix, Gardasil / Silgard, India, Vaccine Politics/People Tagged With: HPV VACCINES, Incia, Supreme Court Case

Comments

  1. Jessica says

    January 16, 2013 at 12:16 pm

    World wide their are concerns about these HPV vaccines, why are we not seeing this on national news?

    Reply
    • admin says

      January 16, 2013 at 8:52 pm

      That is a very good question indeed.

      Reply
  2. Godofredo says

    June 1, 2013 at 4:14 pm

    INEFFICACY OF THE HPV VACCINE SEEN BY DOCTOR OF DEEP PERÚ
    From its inception until the appearance of cervical carcinoma (UCC), takes on average 25 to 40 years, the research of this vaccine have begun in 2000, it is evident that the scientific efficacy of this new vaccine will be determined the years 2025 – 2040.
    HPV not causes definitely the (CCU); at the onset of this disease involves multiple risk factors, including the suspected HPV, but scientificaly is proven by epidemiology and statistics that the sex is what generates this disease .: Mix in 130.000 nuns found not any UCC.
    http://www.portalesmedicos.com/publicaciones/articles/1832/1/Epidemiolog…
    To accept that a virus or a bacteria causes a infection disease must unfailingly fulfill the five Koch’s postulate
    http://www.xatakaciencia.com/salud/los-postulados-de-koch
    1 – The agent must be present in every case of the disease and absent from healthy.
    2 – The agent must not appear in other diseases.
    3 – The agent to be isolated in pure culture from disease lesions.
    4 – The agent of causing disease in a susceptible animal being inoculated.
    5 – The agent must again be isolated lesions in experimental animals.
    http://es.scribd.com/doc/44558220/MICROBIOLOGIA-1
    Consequently, HPV not fulfill not any principle of Koch’s postulate. by not meeting this postulate, that is accepted as dogma in medicine, scientifically we must be ensure that the HPV is not the causative agent to the UCC..
    Until August 2012 this vaccine produced only in the United States: 265.640 adverse events ( 264,162 females, 9490 males and 5290 unknow sex); permnent disability 8910( 8890 females, 90 males and 110 unknow sex), 1220 deaths (1011 females, 70 males and 140 unknow sex), abnormal PAP 4930, cervical dysplasia 1970 and cervical cancer 570
    http://holyhormones.com/vaccinations/hpv-vaccine/hpv-vaccine-adverse-eve…
    http://therefusers.com/?s=cervarix
    The Vaccine efects advers reactions (VAERS) ensures that only complaint between 1% to 10% of the adverse effects produced by this evil vaccine;this figures shown are calculated according to the statements of the VAERS: to 10%.
    http://www.noticiero.enkoria.com/2011/diez-menores-que-sufrieron-reaccio…
    http://www.pop.org/content/merck-researcher-admits-gardasil-guards-again…
    Dr. Harper, who contributed to the development of the vaccine by Merck, reports that the vaccine was not investigated in children under 15 years and the vaccine given to children under 11 years is a big public experiment.
    http://offtheradar.co.nz/vaccines/53-researcher-diane-harper-blasts-gard…
    The vaccine was approved to give girls uncontaminated with HPV, Dr. Howenstinc ensures that the women are vaccinated with HPV contaminated, have the possibility to acquire a 44.6% CCU
    http://www.newswithviews.com / Howenstine/james170.htm.
    Merck did not disclose that the vaccine was transgenic, the Sane Vax has discovered, which is transgenic because it has been found that the vaccine is contaminated with DNA recombinant vaccine Gardasil (DNArPVH) and has raised its concerns to the president of the FDA Margaret Hamburg. The FDA replied that the vaccine will not cause any damage transgenic
    http://real-agenda.com/2011/09/16/vacuna-gardasil-contaminada-con-adn-re…
    http://bolsonweb.com.ar/diariobolson/detalle.php?id_noticia=26075
    A vaccinated child was ill with rheumatoid arthritis, which is an autoimmune disease. 24 hours after vaccination and found that the aluminum adhered to DNArPVH, two years after vaccination and in autopsy 6 months after death in a New Zeland girl Jazmine Renata which had recibed this deadly vaccines
    http://www.mecfsforums.com/index.php?topic=9331.0
    Management time to get market approval of a drug the FDA is at least three years, it is a drug for cancer 15 years, but the authorization Merck had only six months and the European Medicines Agency (EMA in English) only 9 months: To introduce the vaccine are using the marketing of fear
    http://mujeresenaccion.over-blog.es/article-vph-la-vacuna-del-marketing-… http://mujeresenaccion.over-blog.es/article-vph-la-vacuna -of-marketing-of-fear-67210961.ht
    HPV is ubiquitous; lives in wild and domestic animals, pollute us from birth, is on the doorknobs, on towels, on nails, on fomites, in gloves and specula of gynecologists,. sexual intercourse is not the only means of contamination.
    http://spa.myhealthygood.com/cancer-cervical-vacuna-contra-el-vph/invest…
    HPV also lives in the 400 nm outermost of our skin and mucous membranes. ,
    If you live in our skin, our immune system produces cellular and humoral immunity is acquired or that our body is self vaccinatinge by PVHs living on our skin and mucous ..
    http://www.conganat.org/seap/bibliografia/HPVToday/HPVToday007SEAP.pdf
    The PVHs is not distributed uniformly worldwide. It has been found that in Canada HPV 18 only reaches 3%; is more often HPV 31, in my country Peru no studies have determined that HPV types predominate; Gardasil contains 225 mcg. aluminum and Cervarix 500 mcg, that produce the Alzheimer, Parkinson and autism, produce too neurotoxic and immune system disorders (Blaylock 2012) and Polisorbato 80, a powerful contraceptive, that in experimental animals produces sterility, atrophy of the testicles and disturbance organic and funtional of the organs of the reproduction; is carcinogenic and mutagenic; also contains sodium borate considered poison unused in medicinal preparations (NLM)
    http://www.telefonica.net/web2/paramahamsa/vacunaninosalerta.html http://detenganlavacuna.wordpress.com/2010/11/09/gardasil-cervarix/
    Have been discovered to date 200 types of HPV; HPV is not infectious, contagious; the intercourse is not only that the persons is contaminated
    http://quimicaclinicauv.blogspot.com/2006/08/virus-del-papiloma-humano.html http://www-lab.biomedicas.unam.mx/smpv/queeshpv.htm
    On 22-11-2010 FDA approved Gardasil for males aged 9 to 26 to prevent warts and cancer to the anus, is overkill
    http://real-agenda.com/2011/09/16/vacuna-gardasil-contaminada-con-adn-re…
    http://salud.aollatino.com/2011/02/02/aprueba-fda-nueva-indicacion-vacun…
    For the reasons from deep Peru Huancayo, I believe that this vaccine is a fraud?, robbery?, swindle?, rough joke?,crime?
    The HPV is not scientifically proved for the moment that produce the UCC its effectiveness shall be verified just the years of 2025-2040.
    Dr. Godofredo Arauzo
    E mail: godo.ara@ gmail.com

    Reply
  3. Godofredo says

    January 1, 2016 at 2:13 pm

    THE ENIGMATIC HUMAN PAPILLOMA VIRUS

    There are identified 234 types of human papillomavirus (HPV); they are divided in low and high risk; the high risk factor HPV are suspicious to originate the uterine cervical carcinoma (UCC); the low risk the mayority, produce benigns lesions; to day exist world collective psicosis about the HPV by the full advertising to the manufacturer to introduce the vaccine against the HPV in the market.

    There are not researchers; stadistic, epidemiologc, citologic, histologic, colposcopic and clinic to demostrate that this vaccine prevent the pollution with HPV nor the HPV produce the cervical cancer

    HPV infection not only is adquired for the coitus; we are contaminated since after born, are widespread in the world; they life in the environment and blood for reduced time; they are ubiquitous; by immunology are determined that have the affinity by our skin and the mucous membrane of the genital, upper respiratory and digestive tracts; anus, of the mouth, gum, lips, in the amniotic fluid, ruber glove, biopsy forceps, specula, underwear, towels, on the floor, the toilet seat, gyms, lockers rooms of swimming in general in the fomites;: are considered as commensals; the domestic and wild animals too are contaminated.

    In average have the viruses 3% to 93% of the men; between 23-26 years of women have the more high frequency and 40% of children have this virus and the 10% of women without sex have the HPV; the pregnants of the first quarter 40%, of the third quarter 60% and in the postpartum 17% have the HPV. Not all person in the world are contaminated;.in average 10% of persons that are leving in development countries and 15% in underdevelpment are polluted with this viruses; they lack to the cellular structure; they have not the proper metabolism; they request a cell to life, is the parasitic of the cell; they are considered the basic structure of life.The frequency and types of the HPV vary according to the region, geography, age, cultural, social, economic and religious factors; the HPV do not distribuited to iqual in the world; in USA: the more frequecy is PVH 16 , Africa HPV 45 , Central and South America PVH 39-59, Canada HPV 31, Spain HPVs 6-16-51- 53: The HPV is increased in the second time of the menstrual cycles and in women who use hormonal anticonception and decrease in the first time of the cycles and do not use hormonal anticonception; the proportion of the HPV too is diferent over the world: Africa Subsahariana 24%, east of Europe 21.4% , Latin America 16.1%, Thailand 8%, New Mexico both sexo 9%, white no hispanic 13.7% , hispanic 9.7% and natives 6.6% , Argentina 16.6% , South Corea 10.4% and so on; a metanalysis in women with normal PAP 11.7%.The HPV life in the cervix of the uterine without produced disturbance: are latent, subclinical in minority case as warts, condylomata flat or inverted ; The HPV are capricious, ubiquitous and enigmatics, appears and disappears from the body of the person, the highest incidence are in women aged 20 to 26 years disappear with the age, may persist throughout life without causing any disturbance, in 80% of women who have HPV in your cervix disappear before the twelve months, by action of the immune system.

    There are not any investigation that scienrtifically proof that the HPV cause the uterine cervical carcinoma (UCC) it is only suspicious. In the development of the UCC are implicate others cofactors being the first and foremost the sexual act; the coitus is the factor scientifically demostrated that produce the UCC; Mix in 130, 000 nuns do not found not any UCC, followed by fasctor suspísous: tobacco, alcohol, HPV, herpes simplex virus 2, age of first intercourse, number of partners, cofactor man, economic factors, more frequent in women of low economic status , multiparity, circumcision, immune system disorders, hormonal contraception, environment and others.
    In 1974 zur Hausen hypothesized that HPV was the agent that cause the UCC and other researchers reported the same idea, but HPV does not fulfill the five Koch’s postulates, which is accepted as dogma in the scientific medical to be considered as the cause of cervical cancer; the HPV in UCC are found by immunological methods in only 90%, that can consider as that the HPV is present or is a immunology residue; the HPV natural or native do not found.in UCC
    The presence of HPV is not sufficient for the development the UCC, require the company of several exogenous and endogenous cofactors.
    Our understanding of the relationship of HPV with the cofactors are still poor and the role of cofactors in the development of cervical malignancy are nebulous. Scientifically can ensures that HPV does not cause cervical carcinoma and HPV vaccine does not prevent less prevents cervical carcinoma, must have further research on the HPV and other cofactors.
    Dr. Godfrey Arauzo
    Huancayo PERU
    E mail: godo.ara @ gmail.com

    Reply
  4. Eugenio Collis says

    September 22, 2016 at 4:34 am

    Savvy comments ! I was fascinated by the specifics ! Does someone know where I would be able to obtain a template ITA-367 example to fill in ?

    Reply
    • admin says

      September 22, 2016 at 5:05 am

      A pdf is here – http://enforcement.trade.gov/apo/new/367-208-apo-app.pdf

      Reply
    • regina erzbeth says

      September 24, 2016 at 8:22 am

      Hi Eugenio, my colleague filled out a sample ITA-367 document at this site https://goo.gl/oigIkv.

      Reply

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  • Creating an HPV Industry
  • File a VAERS Report
  • Gardasil and Unexplained Deaths
  • HPV Industry Timeline
  • HPV Mechanisms of Action in Women
  • HPV Vaccine Fact Sheet
  • Petition: Rescind HPV Vaccine Approval
  • Presentation to the FDA
  • Supreme Court Arguments

HPV Vaccine VAERS Reports

Description 12/14/2019  TOTAL
Disabled 3,092
Deaths 523
Did Not Recover 13,072
Abnormal Smear 695
Cervical Cancer 186
Infertility 52
Life-threatening 1,001
Emergency Room 15,419
Hospitalized 6,448
Extended Hosp. Stay 304
Serious 9,497
Total Adverse Events 64,270

Access expanded report here.

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