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Prevalence of Human Papillomavirus Types in High-Grade Cervical Intraepithelial Neoplasia and Cancer in Italy

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American Association for Cancer Research
Francesca M. Carozzi1, Maria L. Tornesello2, Elena Burroni1, Giovanna Loquercio2, Giuseppe Carillo3, Claudio Angeloni4, Aurora Scalisi5, Rosalba Macis6, Francesco Chini7, Franco M. Buonaguro2, Paolo Giorgi Rossi7 and for the HPV Prevalence Italian Working Group

Corresponding Author:
Paolo Giorgi Rossi, Laziosanità, Via di Santa Costanza, 53, Rome 00198, Italy. E-mail: giorgirossi@asplazio.it

Abstract

Background: The aim of this multicentric study was to identify human papillomavirus (HPV) type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia 2/3 (CIN2/3) in Italy.

Methods: Cases were sampled through the electronic databases at the pathology units of eight centers in six regions from central and southern Italy. HPV types were detected from paraffin-embedded tissue samples and cervical specimens through amplification of HPV DNA with GP5+/GP6+ primers, followed by genotyping with reverse line blot (RLB). Untyped HPV-positive samples were sequenced. HPV-negative samples underwent nested PCR, followed by either RLB or sequencing. Finally, the remaining HPV-negative samples were amplified with primers targeting the virus E6 to E7 regions.

A National Strategy to Improve Sexual Health

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JAMA

Andrea Swartzendruber, MPH; Jonathan M. Zenilman, MD
JAMA. 2010;304(9):1005-1006. doi:10.1001/jama.2010.1252
Sexual health is an integrated care-delivery and prevention concept that recognizes sexual expression as normative and encompasses preventive and treatment services throughout the life span. However, the United States lacks an integrated approach to sexual health. Public health programs such as sexually transmitted disease (STD)/human immunodeficiency virus (HIV) prevention and family planning are categorically funded and organizationally fragmented, and federal reproductive health programs in the past decade emphasized abstinence. As a result, sexual health indicators are poor.

Prevalence of HPV Infection Among Females in the United States

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JAMA

Eileen F. Dunne, MD, MPH; Elizabeth R. Unger, PhD, MD; Maya Sternberg, PhD; Geraldine McQuillan, PhD; David C. Swan, PhD; Sonya S. Patel, BS; Lauri E. Markowitz, MD

JAMA. 2007;297:813-819.

ABSTRACT

Context – Human papillomavirus (HPV) infection is estimated to be the most common sexually transmitted infection. Baseline population prevalence data for HPV infection in the United States before widespread availability of a prophylactic HPV vaccine would be useful.

Objective – To determine the prevalence of HPV among females in the United States.

Design, Setting, and Participants – The National Health and Nutrition Examination Survey (NHANES) uses a representative sample of the US noninstitutionalized civilian population. Females aged 14 to 59 years who were interviewed at home for NHANES 2003-2004 were examined in a mobile examination center and provided a self-collected vaginal swab specimen. Swabs were analyzed for HPV DNA by L1 consensus polymerase chain reaction followed by type-specific hybridization. Demographic and sexual behavior information was obtained from all participants.

Abnormal Pap tests after the HPV vaccine

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Reprinted from Australian Family Physician Vol. 38, No. 12, December 2009 Stella Heley BA(Hons), MBBS, FAChSHM, is Senior Liaison Physician, Victorian Cytology Service, Melbourne, Victoria. sheley@ vcs.org.au Julia Brotherton BMed(Hons), MPH(Hons), GradDipAppEpi, FAFPHM, is an epidemiologist, National HPV Vaccination Program Register, Victorian Cervical Cytology Registry, Victorian Cytology Service, Melbourne, Victoria. Background Worldwide, cervical cancer affects […]

Heavy Metals and Fertility

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Ingrid Gerhard, Bondo Monga, Andreas Waldbrenner,
Benno Runnebaum
Department of Gynecological Endocrinology and Reproduction,
University Hospital of Obstetrics and Gynaecology, Heidelberg Germany

Heavy metals have been identified as factors affecting human fertility. This study was designed to investigate whether the urinary heavy metal excretion is associated with different factors of infertility. The urinary heavy metal excretion was determined in 501 infertile women after oral administration of the chelating agent 2,3-dimercaptopropane- 1-sulfonic acid (DMPS) .

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