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You are here: Home / RESEARCH . . . . / Gardasil/Silgard Vaccine / Gardasil/Silgard Product Info. / Developing an HPV vaccine to prevent cervical cancer and genital warts

Developing an HPV vaccine to prevent cervical cancer and genital warts

July 5, 2011 By Norma 4 Comments

Bryan JT

Source

Vaccine and Biologics Research, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, United States. janine_bryan@merck.com

Abstract

The challenges of the journey from target identification through development of a prophylactic quadrivalent human papillomavirus (HPV) vaccine have been met in Gardasil. Cervical cancer is the second leading cause of cancer-related death in women worldwide. Approximately 70% of cervical cancer is caused by infection with HPV types 16 and 18 and approximately 90% of genital warts are caused by HPV types 6 and 11. The quadrivalent HPV vaccine was generated by expression of the major capsid protein (L1) of HPV types 16, 18, 6 and 11 in yeast. L1 proteins self assemble into pentamer structures and these pentamer structures come together to form virus-like particles (VLPs). The VLPs are antigenically indistinguishable from HPV virions. The VLPs contain no viral DNA and therefore the vaccine is non-infectious. Gardasil is composed of VLPs of HPV types 16, 18, 6 and 11 conjugated to a proprietary amorphous aluminum hydroxyphosphate sulfate adjuvant. The results of a rigorous clinical program have demonstrated that the vaccine is safe and highly efficacious in preventing dysplasias, cervical intraepithelial neoplasias (CIN 1-3) the precursors of cervical cancer and external genital lesions caused by vaccine-HPV types. In conclusion, Gardasil addresses a major medical need, that is, reduction of HPV-related disease including cervical cancer as a safe, immunogenic, and highly efficacious vaccine.

PMID: 17289220 [PubMed – indexed for MEDLINE]

Related

Filed Under: Gardasil/Silgard Product Info., Human Papillomavirus Research Tagged With: development, HPV vaccine

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  1. SANE Vax Inc. Announces the Discovery of Viral HPV DNA Contaminant in Gardasil | SaneVax says:
    September 6, 2011 at 7:22 am

    […] [v] Developing an HPV vaccine to prevent cervical cancer and genital warts […]

    Reply
  2. SANE Vax Inc. Announces the Discovery of Viral HPV DNA Contaminant in Gardasil | Sovereign Independent says:
    September 6, 2011 at 4:22 pm

    […] [v] Developing an HPV vaccine to prevent cervical cancer and genital warts […]

    Reply
  3. breast cancer vs cervical cancer says:
    June 17, 2012 at 4:17 am

    […] Developing an HPV vaccine to prevent cervical cancer and genital warts […]

    Reply
  4. SANE Vax Inc. Announces the Discovery of Viral HPV DNA Contaminant in Gardasil » Philosophers stone | Philosophers stone says:
    August 17, 2012 at 1:13 pm

    […] [v] Developing an HPV vaccine to prevent cervical cancer and genital warts […]

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