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You are here: Home / NEWS . . . . . . . . / Vaccines / HPV / Cervarix / HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future

HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future

November 2, 2010 By Jonathan 1 Comment

Journal of Translational Medicine 2010, 8:105doi:10.1186/1479-5876-8-105

Luciano Mariani and Aldo Venuti

Published: 27 October 2010

Although long-term protection is a key-point in evaluating HPV-vaccine over time, there is currently inadequate information on the duration of HPV vaccine-induced immunity and on the mechanisms related to the activation of immune-memory. Longer-term surveillance in a vaccinated population is needed to identify waning immunity, evaluating any requirements for booster immunizations to assess vaccine efficacy against HPV-diseases. Current prophylactic vaccines have the primary end-points to protect against HPV-16 and 18, the genotypes more associated to cervical cancer worldwide. Nevertheless, data from many countries demonstrate the presence, at significant levels, of HPVs that are not included in the currently available vaccine preparations, indicating that these vaccines could be less effective in a particular area of the world. The development of vaccines covering a larger number of HPVs presents the most complex challenge for the future. Therefore, long term immunization and cross-protection of HPV vaccines will be discussed in light of new approaches for the future.

Access the entire article here.

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Filed Under: Cervarix, Cervical Cancer HPV, Gardasil / Silgard Tagged With: cervarix, Cervical Cancer HPV, Gardasil/Silgard, HPV, HPV VACCINES, vaccinations, Vaccine Adverse Reactions

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HPV Vaccine VAERS Reports

Description 12/14/2019  TOTAL
Disabled 3,092
Deaths 523
Did Not Recover 13,072
Abnormal Smear 695
Cervical Cancer 186
Infertility 52
Life-threatening 1,001
Emergency Room 15,419
Hospitalized 6,448
Extended Hosp. Stay 304
Serious 9,497
Total Adverse Events 64,270

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