Immunization not linked to increased hospitalization for children with inherited disorder

Press release by Kaiser Parmanente

Study focused on ER visits or hospitalizations in children with inborn errors of metabolism

Children with inborn errors of metabolism received vaccines on the same immunization schedule as did healthy infants, according to Kaiser Permanente Vaccine Study Center scientists who examined the Kaiser Permanente Northern California population. In addition, immunization was not associated with significant increases in emergency room visits or hospitalizations during the month following vaccination, according to Nicola Klein, MD, PhD, lead author of the study and co-director of the Kaiser Permanente Vaccine Study Center.

The study appears in the current online issue of Pediatrics.

The paper is among the first to study immunization rates and vaccine safety in children with inherited metabolic disorders, which is a potential high-risk population for vaccine-preventable illnesses. Inborn errors of metabolism comprise a large class of genetic diseases characterized by defects in enzymes required for breaking down organic compounds, said the researchers. Although each condition is individually rare, it is estimated that the collective birth prevalence is between 1 in 2,500 to 5,000 live births, they explained.

Studying infants with inborn metabolism errors compared with matched healthy controls, similar proportions of children in the Kaiser Permanente Northern California population were up to date for vaccines at 2 years of age, and there was no evidence of delay in receipt of recommended vaccines during the first year, said Klein. Importantly, vaccination of children with inborn errors of metabolism was not associated with significant increases in emergency room visits or hospitalizations during the 30 days after vaccination.

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[Note from SaneVax:  One has to wonder who actually wrote this article and what they were thinking. The definition of the ‘study’ says they compared the ER/hospitalization events at 1-30 days post-vaccination compared to 31-70 days post-vaccination. Even so, the article refers to one hospitalization that did not occur for 17 years. Beyond that obvious question of validity, one can normally assume that as a matter of course you will find more numbers of ER visits or hospitalizations in 60 days than you will in 30 days – no matter what cohort you are looking at. The SaneVax Team wants to know who in their right mind could possibly think this ‘study’ presents any valid evidence of anything?]