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You are here: Home / NEWS . . . . . . . . / Vaccine Adverse Events / Vaccine Associated Disorders / Autism / Link to Autism in Boys Found in Missing DNA

Link to Autism in Boys Found in Missing DNA

September 16, 2010 By Jonathan Leave a Comment

ScienceDaily

(Sep. 15, 2010)

New research from the Centre for Addiction and Mental Health (CAMH) and The Hospital for Sick Children (SickKids), both in Toronto, Canada provides further clues as to why Autism Spectrum Disorder (ASD) affects four times more males than females. The scientists discovered that males who carry specific alterations of DNA on the sole X-chromosome they carry are at high risk of developing ASD.

The research is published in the September 15 issue of Science Translational Medicine.

ASD is a neurological disorder that affects brain functioning, resulting in challenges with communication and social interaction, unusual patterns of behaviour, and often, intellectual deficits. ASD affects one in every 120 children and a startling one in 70 boys. Though all of the causes of ASD are not yet known, research has increasingly pointed towards genetic factors,. In recent years, several genes involved in ASD have successfully been identified.

The research team was led by Dr. John B. Vincent, Senior Scientist and head of CAMH’s Molecular Neuropsychiatry and Development Laboratory and Dr. Stephen Scherer, Senior Scientist and Director of The Centre for Applied Genomics at SickKids, and Director of the McLaughlin Centre at the University of Toronto. The scientists analyzed the gene sequences of 2,000 individuals with ASD, along with others with an intellectual disability, and compared the results to thousands of population controls. They found that about one per cent of boys with ASD had mutations in the PTCHD1 gene on the X-chromosome. Similar mutations were not found in thousands of male controls. Also, sisters carrying the same mutation are seemingly unaffected.

“We believe that the PTCHD1 gene has a role in a neurobiological pathway that delivers information to cells during brain development — this specific mutation may disrupt crucial developmental processes, contributing to the onset of autism.” said Dr. Vincent. “Our discovery will facilitate early detection, which will, in turn, increase the likelihood of successful interventions.”

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Filed Under: Autism, Vaccine Adverse Events Tagged With: autism, vaccinations, Vaccine Adverse Reactions

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