• Home
  • Victims
    • Vaccine Victims Memorial
    • Gardasil & Silgard
      • G / S Australasia
        • G / S Australia
        • G / S New Zealand
      • G / S Europe
        • G / S Czech Republic
        • G / S Denmark
        • G / S France
        • G / S Germany
        • G / S Ireland
        • G / S Italy
        • G / S Norway
        • G / S Scotland
        • G / S Spain
        • G / S United Kingdom
      • G / S N. America
        • G / S Canada
        • G / S Mexico
        • G / S United States
      • G / S S. America
        • G / S Brazil
        • G/S Colombia
    • Cervarix
      • Cervarix Asia
        • Cervarix India
        • Cervarix Philippines
      • Cervarix Europe
        • Cervarix Czech
        • Cervarix Netherlands
        • Cervarix Scotland
        • Cervarix Slovakia
        • Cervarix Spain
        • Cervarix UK
      • Cervarix N. America
        • Cervarix Mexico
  • Resources
    • HPV Testing Resources
      • Pre-HPV Vaccination
      • Post-HPV Vaccination
    • Medical Professionals
    • Vaccine Injury Attorneys
    • Political Action Groups
    • Vaccine Groups
    • Vaccine Victims Hotline
  • SANE Vax Press Releases
  • Videos
    • Vaccine Safety Videos
    • Vaccine Victim Videos
    • Pharma Videos
  • About
    • About Us
    • Who We Are
    • Press Releases
    • SANE Vax in the News
    • Contact Us

SaneVax, Inc.

The First International HPV Vaccine Information Clearinghouse

  • NEWS
    • Government Agencies
      • African
      • Asian
      • Australasian
      • European
      • North American
      • South American
      • United Nations
      • WHO
    • Pharmaceutical Companies
      • CSL Biotherapies
      • GlaxoSmithKline
      • Inovio Pharmaceuticals
      • Liquidia Technologies
      • Merck & Co.
      • Novartis
      • Pfizer
      • Qiagen
      • Sanofi Aventis
      • Sanofi Pasteur MSD spmsd
      • Wyeth Laboratories
    • Science & Medicine
      • Cancer
      • Clinical Trials
      • Environmental Health
      • Heavy Metal Toxicity
      • HPV Science
      • Influenza
      • Meningitis
      • Pertussis
      • Pharmaceuticals
      • Rotavirus
      • STD’s
      • Vaccine Science
      • Women’s Health
    • Vaccine Adverse Events
    • Vaccine Injury Reporting
      • VAERS
      • VAMPSS
    • Vaccine Litigation
    • Vaccine Marketing
    • Vaccine Politics/People
    • Vaccine Victims
      • Cervarix Injuries
      • DTP/DTaP Injuries
      • Fluvax Injuries
      • Fluzone Injuries
      • Gardasil / Silgard Injuries
      • Menomune Injuries
      • MMR Injuries
      • Polio Vaccine Injuries
      • Synflorix Injuries
      • Yellow Fever Vaccine
    • Vaccines
      • Anthrax
      • Breast Cancer
      • Chicken Pox
      • Cholera
      • Combination Vaccines
      • Diphtheria
      • Hepatitis B
      • HPV
      • Influenza Vaccines
      • Malaria
      • Measles
      • Meningitis Vaccines
      • MRSA
      • Mumps
      • Norovirus
      • Pertussis Vaccines
      • Pneumococcal Disease
      • Polio
      • Rotavirus Vaccines
      • Shingles
      • Smallpox
      • TB
      • Tetanus
      • Typhoid
      • Yellow Fever Vaccine
    • Vaccines and the Media
  • WORLD NEWS
    • Africa
    • Asia
    • Australasia
    • Europe
    • North America
    • South America
  • RESEARCH
    • Cancer Research
    • Cervarix Vaccine
    • Gardasil/Silgard Vaccine
    • Human Pap. Research
    • Immunization Practices
    • Neurology
    • Vaccine Adjuvants
    • Vac. Ingredient Research
    • Vaccine Injuries
    • Vaccine Preservatives
    • Vaccine Related Research
    • Vaccine Safety
  • CITIZENS SPEAK
    • Cervical Cancer Debate
    • HPV Vax
      • Australian Concerns
      • Canadian Concerns
      • Irish Concerns
      • Spain Concerns
      • UK Concerns
      • United States Concerns
You are here: Home / NEWS . . . . . . . . / Vaccine Adverse Events / Endocrine System / Lymphocytic Hypophysitis

Lymphocytic Hypophysitis

July 17, 2011 By Jonathan Leave a Comment

LSU Medical Center

Greg Dowd, MD and Deepak Awasthi, MD
Department of Neurosurgery; LSU Medical Center; New Orleans, LA

Introduction:
Lymphocytic hypophysitis (LH) is an important cause of pituitary dysfunction in the young female. Multiple reports in the last 15 years have helped to clarify this disorder as an auto immune inflammation of the pituitary gland. This process can lead to both endocrine dysfunction and/ or gland enlargement with compression of visual pathway structures. As treatment strategies for this condition differ from other lesions of the pituitary, recognition of this diagnosis is crucial.

The pathology of LH was first described in 1962 in a young postpartal female who died of shock following an appendectomy (7). She was found to have marked adrenal atrophy in addition to fibrosis and lymphocytic invasion of her piuitary gland. Subsequent autopsy reports in young postpartum females followed suggesting a dismal course for lymphocytic hypophysitis. However, in 1980 an antemortem diagnosis and successful outcome was documented in a patient that under went a trans- sphenoidal resection of a suspected pituitary tumor (9). Since this time, several indicators suggest thst this rarely diagnosed condition is probably much more common than previously suspected.

LSU Experience:
During the period 1993-6, three patients with lymphocytic hypophysitis presented to the neurosurgical service. All three patients were young females in the early post partum period with headaches and visual field deficits. Table 1 provides a summary of their clinical picture at presentation.

TABLE 1
Lymphocytic Hypophysitis
LSU Experience 1993-1996

Age Months
Post-partum
Symptoms Endocrine MRI
26 2 * Headache
* Right homonymous visual field deficit
low TSH
low FTI
* non-aerated cells
* contrast-enhancing
lesion
* suprasellar ext.
27 >5 >* Headache (1 year)
* Nipple discharge
* Amenorrhea
* Left temporal mon-
ocular anopsia
PRL: 96 * suprasellar ext.
28 5 * Headache normal * 1.5×2.5cm contrast-enhancing lesion
* suprasellar ext with chiasmatic compression

TSH: Thyroid stimulating hormone
FTI: Free Thyroid Index
PRL: Prolactin
ext: extension

Case History:
A.H. is a 26 yo black female who was previously healthy and five months postpartum from a normal vaginal delivery. She had complained of headaches since delivery and persistent amenorrhea despite bottle feeding. She noticed a right temporal visual field deficit one month prior to neurosurgical evaluation. An MRI (Figure 1) demonstrated a 2.0 x 2.5 cm lesion with suprasellar extension and chiasmal compression. This had diffuse enhancement with contrast, including the infundibular area.

The patient underwent near total hypophysectomy via the trans-sphenoidal route with decompression of the chiasm. The pituitary tissue was found to be brownish and fibrous. Microscopic evaluation showed fibrous inflammatory tissue surrounding clumps of pituitary tissue. A decadron stress dose and taper over a ten day period was also given. Post-operatively, the patient had transient diabetes insipidus necessitating DDAVP for four days and had resolution of her headaches and visual field deficit. A follow up MRI done two months later showed a normal pituitary gland without enhancement and a decompressed optic chiasm.

Discussion:
The cases presented here serve to illuminate and confirm the most common presentation of lymphocytic hypophysitis. Although described in both sexes (1) and in all age groups from adolescence until old age, young females either during pregnancy or immediately post partum comprise the bulk of the patients.

Pathophysiology:
The occurrence of pituitary inflammation associated with pregnancy is felt to be secondary to the involution of the pituitary gland that takes place during this time (4,7). Under the influence of estrogen during pregnancy, the pituitary gland increases in size up to 400% (6). This rapidly returns to baseline following parturition. Serologic examination of women one week following normal delivery demonstrated that 18% developed anti- pituitary antibodies (5). It was noted that those with antibodies present had a much higher incidence of pituitary insufficiency. This suggests that pregnancy induced reaction against the pituitary gland may affect a potentially large group of women with a range of pathologic changes. It is entirely possible that those women diagnosed with lymphocytic hypophysitis due to a visual defect or gross hormonal change represent only the tip of the iceberg.

In women with the appropriate immune background, an auto immune response is generated. Amongst one group of LH patients, a 24% prevalence of other auto immune disorders was identified (11). Thyroiditis was the most common disorder amongst this group. Several of the cases of LH have not been associated with pregnancy but their was an history of an antecedent viral illness. Possibly an altered immune reaction to the viral antigens cross reacted with the pituitary tissue. This suggests that lymphocytic hypophysitis may be the final common pathway for several combinations of genetic backgrounds and antigen combinations.

 

Read Full Study – could not find a date of publication.

Related

Filed Under: Endocrine System, Nervous System, Reproductive System Tagged With: autoimmune disorders, Lymphocytic hypophysitis (LH), pituitary inflammation

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Follow Us

SaneVax on FacebookSaneVax on TwitterSaneVax on LinkedInSaneVax on YoutubeSaneVax RSS Feed

Help Support SaneVax

Notice: We need your support. This massive research & presentation comes from a team of volunteers. We need your help to keep this critical information available.



SaneVax relies on support from participants like you. We are a 501 (c)(3) non-profit corporation, donations are tax deductible. Help keep this venue available and support the spirit – Thank you!

This Week’s Survivor

Vaccines: A descent into madness

Categories

Links

  • Creating an HPV Industry
  • File a VAERS Report
  • Gardasil and Unexplained Deaths
  • HPV Industry Timeline
  • HPV Mechanisms of Action in Women
  • HPV Vaccine Fact Sheet
  • Petition: Rescind HPV Vaccine Approval
  • Presentation to the FDA
  • Supreme Court Arguments

HPV Vaccine VAERS Reports

Description 12/14/2019  TOTAL
Disabled 3,092
Deaths 523
Did Not Recover 13,072
Abnormal Smear 695
Cervical Cancer 186
Infertility 52
Life-threatening 1,001
Emergency Room 15,419
Hospitalized 6,448
Extended Hosp. Stay 304
Serious 9,497
Total Adverse Events 64,270

Access expanded report here.

Related

Subscribe2


 

Log In

Featured Video

dangers

The Dangers of Vaccines – Part 1 (Autism MMR HPV Gardasil Swine Flu H1N1 Thimerosal)

News

SaneVax News Blog!
News

Videos

Safety • Victims • Pharma
No Genetic Epidemic

Contact

Contact S.A.N.E.Vax
S.A.N.E.VAX log thumbnail

Copyright © 2023 SaneVax, Inc. · Site by TheWebElves.com a div. of KalaRhythms.org · Log in