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Prevalence of Human Papillomavirus Types in High-Grade Cervical Intraepithelial Neoplasia and Cancer in Italy

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American Association for Cancer Research
Francesca M. Carozzi1, Maria L. Tornesello2, Elena Burroni1, Giovanna Loquercio2, Giuseppe Carillo3, Claudio Angeloni4, Aurora Scalisi5, Rosalba Macis6, Francesco Chini7, Franco M. Buonaguro2, Paolo Giorgi Rossi7 and for the HPV Prevalence Italian Working Group

Corresponding Author:
Paolo Giorgi Rossi, Laziosanità, Via di Santa Costanza, 53, Rome 00198, Italy. E-mail: giorgirossi@asplazio.it

Abstract

Background: The aim of this multicentric study was to identify human papillomavirus (HPV) type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia 2/3 (CIN2/3) in Italy.

Methods: Cases were sampled through the electronic databases at the pathology units of eight centers in six regions from central and southern Italy. HPV types were detected from paraffin-embedded tissue samples and cervical specimens through amplification of HPV DNA with GP5+/GP6+ primers, followed by genotyping with reverse line blot (RLB). Untyped HPV-positive samples were sequenced. HPV-negative samples underwent nested PCR, followed by either RLB or sequencing. Finally, the remaining HPV-negative samples were amplified with primers targeting the virus E6 to E7 regions.

Women & Children First – Politician rediscovers Chivalry in Gardasil Debate

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ComeLook.org
10 September 2010
Although it’s very unusual for an ambitious politician to tell a potential voter to not communicate with him (“not to waste politician’s time”), in Ireland at least, highlighting the “not appropriate” subject of vaccine safety can provoke such a response.

When a campaigner wrote two short emails to a Wexford local politician in late 2008 raising concerns about the HPV vaccine Gardasil and suggesting he do some research into the associated side effects, the local politician’s response was “Please refrain from sending me any further misinformed and unrequested junk spam”.

Mairead Hilliard, of Irish Vaccine Informed Parents, wrote to Counciller Joe Ryan (now Mayor of Wexford, pop 18000), after she noticed that he had joined an online Facebook group campaigning for reinstatement of the cervical cancer mass vaccination program in Ireland.

MOTHERS ALLIANCE IRELAND CALLS ON THE GOVERNMENT TO STOP THE SCHOOLS’ VACCINATION CAMPAIGN IMMEDIATELY, IN THE BEST INTERESTS OF THE NATION’S CHILDREN.

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SANE Vax.org

September 10, 2010. Mothers Alliance Ireland claims THE SCHOOLS VACCINATION CAMPAIGN, which is to be rolled out this month in Irish Schools for 12/13 year-old girls, poses a serious risk to the lives, health and welfare of Irish children, and it MUST BE ABANDONED IMMEDIATELY.

“Critical information concerning the Gardasil vaccine is being withheld from parents and the public and as a result parents are being denied the right to make a valued and fully informed decision about whether or not to consent to getting their daughters vaccinated”, said Mrs. Nora Bennis, MAI spokesperson. MAI has written to the Minister for Health and Minister for Education outlining the very serious concerns the group has about the safety, efficacy and necessity of this vaccine.

Th1 cytokine patterns in cervical human papillomavirus infection.

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PubMed.gov

Clin Diagn Lab Immunol. 1999 Sep;6(5):751-5.

Scott M, Stites DP, Moscicki AB.

Department of Pediatrics, University of California, San Francisco, California 94143, USA. mscott@itsa.ucsf.edu
Abstract

The host’s immune response to cervical human papillomavirus (HPV) infection is poorly understood. In a longitudinal cohort of women with cervical HPV infections, defined by PCR-based HPV DNA testing, we used exfoliated cervical cells and reverse transcription-PCR to examine the cervical mucosal mRNA expression of cytokines involved in regulating cell-mediated immunity. We identified seven HPV-positive subjects who were found to have cleared their HPV infections 4 months later. In all seven, a T-helper type 1 (Th1) cytokine pattern (expression of gamma interferon and absence of interleukin-4) preceded clearance. The more variable cytokine patterns seen in HPV-negative subjects suggest that the Th1 pattern in the women with subsequent clearance was a response to the HPV infection.

India halts HPV vaccine trial after six girls die, US does nothing in response to 67 deaths and counting

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Natural News

September 1, 2010

The horrors caused by Merck & Co.’s Gardasil vaccine and GlaxoSmithKline’s (GSK) Cervarix vaccine continue as six young girls recently died from the shots during an experimental Indian trial. The two human papillomavirus (HPV) vaccines have been implicated in at least 67 deaths in the U.S., prompting no response from U.S. officials other than to keep pushing it on the public, but the six deaths in India have prompted the government there to immediately stop all trials of the vaccines.

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