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You are here: Home / RESEARCH . . . . / Vaccine Ingredient Research / Polysorbates / Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

July 30, 2015 By Norma

Authors: Coors EA1, Seybold H, Merk HF, Mahler V.

Abstract

BACKGROUND:

Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has declined during the past decades, it is of current relevance as a “hidden” inductor of anaphylactoid reactions.

OBJECTIVE:

To identify polysorbate 80 (generally believed to be an inert vehicle) as an inductor of a severe anaphylactoid reaction.

METHODS:

Skin prick testing, enzyme-linked immunosorbent assay, IgE immunoblotting, and flow cytometric detection of basophil activation were performed in controls and in a patient with a medical history of anaphylactic shock due to intravenous administration of a multivitamin product during pregnancy.

RESULTS:

Polysorbate 80 was identified as the causative agent for the anaphylactoid reaction of nonimmunologic origin in the patient. Polysorbate specific IgE antibodies were not identified in enzyme-linked immunosorbent assay and immunoblot examinations, confirming the nonimmunologic nature of the anaphylactoid reaction.

CONCLUSIONS:

Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions.

PMID: 16400901 [PubMed – indexed for MEDLINE.
Access entire paper here.

Related

Filed Under: Polysorbates Tagged With: anaphylactoid reactions, polysorbate 80

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Description 12/14/2019  TOTAL
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