Authors: Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]
Nanoparticulate systems for brain delivery of drugs.
Kreuter J. Institut für Pharmazeutische Technologie, Biozentrum, J.W.Goethe-Universität, D-60439 Frankfurt, Germany. kreuter@em.uni-frankfurt.de Abstract The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to […]
Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.
Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, Von Briesen H. Eur J Neurosci. 2000 Jun;12(6):1931-40. Abstract Certain drugs such as dalargin, loperamide or tubocurarine are not transported across the blood-brain barrier (BBB) and therefore exhibit no effects on the central nervous system. However, effects on the central nervous system can […]
DELAYED EFFECTS OF NEONATAL EXPOSURE TO TWEEN 80 ON FEMALE REPRODUCTIVE ORGANS IN RATS
M. GAJDOV, J. JAKUBOVSKY, and J. VALKY *Institute of Preventive and Clinical Medicine, Limbov~i 14, 833 01 Bratislava, lnstitute of Pathologic Anatomy, Medical Faculty, Comenium University, and :~Clinic of Gynaecology and Obstetrics, Teaching Hospital, Bratislava, Czechoslovakia (Accepted 23 October 1992) Abstract–Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or […]
