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Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

July 30, 2015 By Norma

Authors: Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]

Filed Under: Polysorbates Tagged With: anaphylactoid reactions, polysorbate 80

Nanoparticulate systems for brain delivery of drugs.

March 15, 2011 By Norma

Kreuter J. Institut für Pharmazeutische Technologie, Biozentrum, J.W.Goethe-Universität, D-60439 Frankfurt, Germany. kreuter@em.uni-frankfurt.de Abstract The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to […]

Filed Under: Polysorbates Tagged With: drug delivery to the brain, nanoparticles

Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.

March 15, 2011 By Norma

Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, Von Briesen H. Eur J Neurosci. 2000 Jun;12(6):1931-40. Abstract Certain drugs such as dalargin, loperamide or tubocurarine are not transported across the blood-brain barrier (BBB) and therefore exhibit no effects on the central nervous system. However, effects on the central nervous system can […]

Filed Under: Polysorbates Tagged With: blood brain barrier, nanoparticles, polysorbate 80

DELAYED EFFECTS OF NEONATAL EXPOSURE TO TWEEN 80 ON FEMALE REPRODUCTIVE ORGANS IN RATS

February 2, 2011 By Norma

M. GAJDOV, J. JAKUBOVSKY, and J. VALKY  *Institute of Preventive and Clinical Medicine, Limbov~i 14, 833 01 Bratislava, lnstitute of Pathologic Anatomy, Medical Faculty, Comenium University, and :~Clinic of Gynaecology and Obstetrics, Teaching Hospital, Bratislava, Czechoslovakia (Accepted 23 October 1992) Abstract–Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or […]

Filed Under: Polysorbates Tagged With: infertility

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Cervarix: New medical conditions for both my daughters

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HPV Vaccine VAERS Reports

Description 12/14/2019  TOTAL
Disabled 3,092
Deaths 523
Did Not Recover 13,072
Abnormal Smear 695
Cervical Cancer 186
Infertility 52
Life-threatening 1,001
Emergency Room 15,419
Hospitalized 6,448
Extended Hosp. Stay 304
Serious 9,497
Total Adverse Events 64,270

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