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You are here: Home / RESEARCH . . . . / Cervarix Vaccine / Cervarix Efficacy / Population-level impact and herd effects following human papillomavirus vaccination  programmes:

Population-level impact and herd effects following human papillomavirus vaccination  programmes:

May 5, 2015 By admin Leave a Comment

a systematic review and meta-analysis

Authors: Mélanie Drolet, PhD†, Élodie Bénard, BSc, Marie-Claude Boily, PhD, Hammad Ali, PhD, Louise Baandrup, MD, Heidi Bauer, MD, Simon Beddows, PhD, Jacques Brisson, DSc, Julia M L Brotherton, BMed, Teresa Cummings, BA, Basil Donovan, MD, Christopher K Fairley, PhD, Elaine W Flagg, PhD, Anne M Johnson, MD, Jessica A Kahn, MD, Kimberley Kavanagh, PhD, Susanne K Kjaer, MD, Erich V Kliewer, PhD, Philippe Lemieux-Mellouki, MSc, Lauri Markowitz, MD, Aminata Mboup, MSc, David Mesher, MSc, Linda Niccolai, PhD, Jeannie Oliphant, FAChSHM, Kevin G Pollock, PhD, Kate Soldan, PhD, Pam Sonnenberg, PhD, Sepehr N Tabrizi, PhD, Clare Tanton, PhD, Dr. Marc Brisson, PhD†
†Joint first authors
Published Online: 02 March 2015
.

Summary

Background

Human papillomavirus (HPV) vaccination programmes were first implemented in several countries worldwide in 2007. We did a systematic review and meta-analysis to assess the population-level consequences and herd effects after female HPV vaccination programmes, to verify whether or not the high efficacy reported in randomised controlled clinical trials are materialising in real-world situations.

Methods

We searched the Medline and Embase databases (between Jan 1, 2007 and Feb 28, 2014) and conference abstracts for time-trend studies that analysed changes, between the pre-vaccination and post-vaccination periods, in the incidence or prevalence of at least one HPV-related endpoint: HPV infection, anogenital warts, and high-grade cervical lesions. We used random-effects models to derive pooled relative risk (RR) estimates. We stratified all analyses by age and sex. We did subgroup analyses by comparing studies according to vaccine type, vaccination coverage, and years since implementation of the vaccination programme. We assessed heterogeneity across studies using I2and χ2 statistics and we did trends analysis to examine the dose–response association between HPV vaccination coverage and each study effect measure.

Findings

We identified 20 eligible studies, which were all undertaken in nine high-income countries and represent more than 140 million person-years of follow-up. In countries with female vaccination coverage of at least 50%, HPV type 16 and 18 infections decreased significantly between the pre-vaccination and post-vaccination periods by 68% (RR 0·32, 95% CI 0·19–0·52) and anogenital warts decreased significantly by 61% (0·39, 0·22–0·71) in girls 13–19 years of age. Significant reductions were also recorded in HPV types 31, 33, and 45 in this age group of girls (RR 0·72, 95% CI 0·54–0·96), which suggests cross-protection. Additionally, significant reductions in anogenital warts were also reported in boys younger than 20 years of age (0·66 [95% CI 0·47–0·91]) and in women 20–39 years of age (0·68 [95% CI 0·51–0·89]), which suggests herd effects. In countries with female vaccination coverage lower than 50%, significant reductions in HPV types 16 and 18 infection (RR 0·50, 95% CI 0·34–0·74]) and in anogenital warts (0·86 [95% CI 0·79–0·94]) occurred in girls younger than 20 years of age, with no indication of cross-protection or herd effects.

Interpretation

Our results are promising for the long-term population-level effects of HPV vaccination programmes. However, continued monitoring is essential to identify any signals of potential waning efficacy or type-replacement.

Funding

The Canadian Institutes of Health Research.

Access entire article here.

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Filed Under: Cervarix Efficacy, Gardasil/Silgard Efficacy, HPV vaccine research Tagged With: HPV vaccination programs, impact

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