Authors: Claire P. Reese, Petra Brhlikova, Allyson M. Pollock Abstract Summary We conducted a critical appraisal of published Phase 2 and 3 efficacy trials in relation to the prevention of cervical cancer in women. Our analysis shows the trials themselves generated significant uncertainties undermining claims of efficacy in these data. There were 12 randomised control […]
The impact of HPV vaccination on future cervical screening: a simulation study of two birth cohorts in Denmark
Authors: Mie Sara Hestbech, Elsebeth Lynge, Jakob Kragstrup, Volkert Siersma, Miguel Vazquez-Prada Baillet, John Broderson Abstract: Objectives To explore the interplay between primary and secondary prevention of cervical cancer by estimating future screening outcomes in women offered human papillomavirus (HPV) vaccination when they were sexually naïve. Design Estimation of outcome of liquid-based cytology screening for a post-HPV vaccination […]
Prophylactic HPV Vaccines: Current Knowledge of Impact on Gynecological Premalignancies
Authors: Diane M. Harper and Karen B. Williams Abstract: Approaches for cervical cancer prevention are changing. Screening still remains the most effective method for cervical cancer prevention. Guidelines are moving to an older group of women to be screened less frequently with combinations of technologies that include biomarkers and cytology. HPV vaccination is an appropriate option for […]
Reduction in HPV Prevalence— No Evidence to Support HPV Vaccination reduces HPV Prevalence
Authors: Jennifer A. Groner1, George D. Harris2 and Diane M. Harper3,4,5 TO THE EDITOR—The recent Centers for Disease Control and Prevention (CDC) study by Markowitz et al [1] provides limited and inconclusive data on 111 sexually active females between 14 and 19 years of age who received at least 1 dose of quadrivalent human papillomavirus vaccine (HPV4). The […]
Population-level impact and herd effects following human papillomavirus vaccination programmes:
a systematic review and meta-analysis Authors: Mélanie Drolet, PhD†, Élodie Bénard, BSc, Marie-Claude Boily, PhD, Hammad Ali, PhD, Louise Baandrup, MD, Heidi Bauer, MD, Simon Beddows, PhD, Jacques Brisson, DSc, Julia M L Brotherton, BMed, Teresa Cummings, BA, Basil Donovan, MD, Christopher K Fairley, PhD, Elaine W Flagg, PhD, Anne M Johnson, MD, Jessica A Kahn, MD, Kimberley Kavanagh, PhD, Susanne K Kjaer, MD, Erich V Kliewer, PhD, Philippe Lemieux-Mellouki, MSc, Lauri Markowitz, MD, Aminata Mboup, […]
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