By: Nikolai Petrovsky, Susanne Heinzel, Yoshikazu Honda, and A. Bruce Lyons A major unsolved challenge in development is how to achieve a potent adjuvant effect while avoiding reactogenicity or toxicity. Older vaccines made from live or killed whole organisms were effective, but suffered from high reactogenicity. As vaccine manufacturers developed safer, less reactogenic subunit vaccines, […]
Vaccine Excipients and Media Summary
Excipients are inactive ingredients of a drug product necessary for production of a finished pharmaceutical formulation. Growth media are culture materials used to produce mass quantities of micro-organism antibodym, or other immunologic agent, suitable for further processing into a pharmaceutical. Below is a summary of the excipients and culture media included in most vaccines licensed […]
Vaccine Hypersensitivity – Update and Overview
By: Philipp J. Fritsche, et al. Summary Concerns about possible reactions to vaccines or vaccinations are frequently raised. However, the rate of reported vaccine-induced adverse events is low and ranges between 4.8–83.0 per 100 000 doses of the most frequently used vaccines. The number of true allergic reactions to routine vaccines is not known; estimations […]
Aluminum Hydroxide Injections Lead to Motor Deficits and Motor Neuron Degeneration
Authors: Christopher Shaw/Michael Petrik 10 Feb 2010 Abstract: Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990–1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except […]
Confirmation Of High Efficacy Of HPV Vaccine Against Precancerous Cervical Lesions And Protective Effect Of Vaccination Programs
Article Date: 07 Jul 2009 – 0:00 PDT The findings of the PATRICIA study are reported in an article Online First and in a future edition of The Lancet. It shows that the HPV-16/18 AS04-adjuvanted vaccine (GlaxoSmithKline) has high efficacy against the precancerous cervical lesions that can eventually lead to cervical cancer. There is confirmation […]
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