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Vaccine adjuvants: Current state and future trends

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Future Trends Authors: Nikolai Petrovsky1 and Julio César Aguilar2 Abstract The problem with pure recombinant or synthetic antigens used in modern day vaccines is that they are generally far less immunogenic than older style live or killed whole organism vaccines. This has created a major need for improved and more powerful adjuvants for use in these vaccines. With […]

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Anti HPV antibodies Levels among vaccinated and non-vaccinated Ugandan Girls

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The levels of anti-HPV16/18 and anti-HPV31/33/35/45/52/58 antibodies among AS04-adjuvanted HPV16/18 vaccinated and non-vaccinated Ugandan girls aged 10–16 years Miriam Nakalembe1*, Cecily Banura2, Proscovia B Namujju34 and Florence M Mirembe1 Abstract Background Data on Human Papilloma virus (HPV) vaccine immune response in sub-Saharan Africa is still sparse yet such knowledge is critical for optimal implementation and monitoring […]

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Merrill W. Chase, Scientist Who Advanced Immunology, Dies at 98

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By Anahad O’Conner, The New York Times Originally published 22 January 2004: Dr. Merrill W. Chase, an immunologist whose research on white blood cells helped undermine the longstanding belief that antibodies alone protected the body from disease and micro-organisms, died on Jan. 5 at his home in New York City, according to the Rockefeller University, […]

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Vaccines as 'Cluster Bombs'

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By Rowan Contraho [Excerpts] Shiv Chopra, the Canadian microbiologist known for having helped stop the approval of rBGH, did so not by making true but complex arguments about its association to cancers, but by reducing the issue to an undeniable biological fact and thus simple legal issue. “A vaccine is a biological preparation that improves […]

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Equality of the sexes? Not always when it comes to biology, 'Man-flu' is real.

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By MaxWild Montreal, May 11, 2009 – When it comes to immunity, men may not have been dealt an equal hand. According to Cambridge University researchers, evolutionary factors have led to the male system becoming more vulnerable to illness. MUHC researchers demonstrate that estrogen renders the innate immune system of women more powerful than that […]

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US Government & Scientists Agree: More Vaccine-Caused-Autism Research Necessary

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By David Kirby The vaccine-autism debate is far from over. If anything, it is just getting started. As the following comments, funding decisions, research priorites and published papers suggest, the US government and many scientists will be researching and discussing this topic for years to come. Here are some reasons why: I) FEDERAL HEALTH AGENCIES […]

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More Flexible HPV Vaccines

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(Ivanhoe Newswire) — Administration of human papillomavirus (HPV) vaccine doses over a longer period of time to adolescent girls in Vietnam resulted in antibody concentration levels that were comparable to the standard vaccine schedule, according to a new study. Cervical cancer is an important cause of illness and death among women throughout the world. “Each […]

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Research opens door to vaccines that can circumvent maternal antibodies

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By Emily Caldwell COLUMBUS, Ohio – New research that reveals how maternal antibodies block an immune response to the measles virus is a first step toward improving current childhood vaccination practices, scientists say. Maternal antibodies are passed to fetuses during pregnancy and to newborns in their mothers’ milk. The antibodies protect infants against disease in […]

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Vaccine Provocation of Stealth Adapted Virus Induced Encephalopathy (VP-SAVIE)

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By W. John Martin, MD, PhD., Institute of Progressive Medicine Vaccination is intended to stimulate the body’s immune response against specific microorganisms or their toxic products. Vaccination is typically the administration via injection of non-living, or otherwise attenuated (weakened), microorganisms or antigenic products, along with an adjuvant intended to enhance the recipient’s immune response. With […]

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NIH Funding Bioterror Vaccines

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Posted in ‘Drug Discovery & Development 08 October 2010 The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, announced three new contracts to fund research on vaccines to protect against emerging infectious diseases and biological threats that could be used in a terror attack. Each project focuses on […]

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Do Flu Vaccinations for Pregnant Women Protect Infants?

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By:  Nancy Solomon 18 October 2010 NIH-Funded Vaccine Research at SLU Also Examines Mom’s Immune Response  ST. LOUIS – In the wake of the 2009 H1N1 influenza pandemic, the National Institutes of Health has launched a clinical trial that studies the seasonal flu vaccine in pregnant women. Saint Louis University, one of the Vaccine and […]

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New-Age Vaccine Adjuvants: Friend or Foe?

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By:  Nikolai Petrovsky, Susanne Heinzel, Yoshikazu Honda, and A. Bruce Lyons A major unsolved challenge in development is how to achieve a potent adjuvant effect while avoiding reactogenicity or toxicity. Older vaccines made from live or killed whole organisms were effective, but suffered from high reactogenicity. As vaccine manufacturers developed safer, less reactogenic subunit vaccines, […]

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Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients

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This study is currently recruiting participants. Verified by University of Alberta, February 2010 Official Title Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients Purpose Human papillomavirus (HPV) affects a significant number of transplant patients. In women, human papillomavirus (HPV) causes genital warts, pre-cancerous areas of the cervix, and cervical cancer. […]

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Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease

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This study is currently recruiting participants. Verified by Mayo Clinic, July 2010 Official Title: Comparison of Immune Response to the Human Papillomavirus Vaccine in Young Women With and Without Inflammatory Bowel Disease Purpose The Gardasil vaccine, a vaccine targeted towards the human papillomavirus (HPV), has been shown to prevent the transmission of several strains of […]

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A Study to Evaluate the Safety, Immune Response, and Efficacy of Gardasil (V501) in Women

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This study is ongoing, but not recruiting participants. Official Title Safety, Immunogenicity, and Efficacy of Gardasil (V501 (Human Papilloma Virus [Types 6, 11, 16, 18] Recombinant Vaccine) in Mid-Adult Women – The FUTURE III (Females United to Unilaterally Reduce Endo/Ectocervical Cancer) Study Detailed Description: The original base protocol was extended. Subjects in the placebo arm […]

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