JAMA. 2007;298:743-753. Main Outcome Measures Presence of HPV DNA was determinedin cervical specimins by a molecular hybridization assay usingchemiluminescence with HPV RNA probes and by polymerase chainreaction using SPF10 primers and a line probe assay detectionsystem before vaccination and by polymerase chain reaction aftervaccination. We compared rates of type-specific viral clearanceusing generalized estimating equations methods at […]
Confirmation Of High Efficacy Of HPV Vaccine Against Precancerous Cervical Lesions And Protective Effect Of Vaccination Programs
Article Date: 07 Jul 2009 – 0:00 PDT The findings of the PATRICIA study are reported in an article Online First and in a future edition of The Lancet. It shows that the HPV-16/18 AS04-adjuvanted vaccine (GlaxoSmithKline) has high efficacy against the precancerous cervical lesions that can eventually lead to cervical cancer. There is confirmation […]
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women
The Lancet, Volume 374, Issue 9686, Pages 301 – 314, 25 July 2009 Background The human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine was immunogenic, generally well tolerated, and effective against HPV-16 or HPV-18 infections, and associated precancerous lesions in an event-triggered interim analysis of the phase III randomised, double-blind, controlled PApilloma TRIal against Cancer In young Adults […]
Prophylactic HPV Vaccines: Current Knowledge of Impact on Gynecological Premalignancies
Authors: Diane M. Harper/Karen B. Williams Published 3 July 2010, Discovery Medicine Abstract: Approaches for cervical cancer prevention are changing. Screening still remains the most effective method for cervical cancer prevention. Guidelines are moving to an older group of women to be screened less frequently with combinations of technologies that include biomarkers and cytology. HPV […]
Human Papillomavirus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18
Completed 29 June 2010 Purpose: Human Papilloma virus (HPV) are viruses that cause a common infection of the skin and genitals in men and women. Several types of HPV infection are transmitted by sexual activity and, in women, can infect the cervix (part of the uterus or womb). This infection often goes away by itself, […]
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