J. Douglas Bremner, Peter McCaffery Abstract Current models of affective disorders implicate alterations in norepinephrine, serotonin, dopamine, and CRF/cortisol; however treatments targeted at these neurotransmitters or hormones have led to imperfect resolution of symptoms, suggesting that the neurobiology of affectivedisorders is incompletely understood. Until now retinoids have not been considered as possible contributors to affective […]
Estrogenic Activity of Coumestrol, DDT, and TCDD in Human Cervical Cancer Cells
Kenneth Ndebele, Barbara Graham, and Paul B. Tchounwou ABSTRACT: Endogenous estrogens have dramatic and differential effects on classical endocrine organ and proliferation. Xenoestrogens are environmental estrogens that have endocrine impact, acting as both estrogen agonists and antagonists, but whose effects are not well characterized. In this investigation we sought to delineate effects of xenoestrogens. Using […]
Oral Contraceptives and Cancer Risk: Questions and Answers
Published by the National Cancer Institute Introduction Oral contraceptives (OCs) first became available to American women in the early 1960s. The convenience, effectiveness, and reversibility of action of birth control pills (popularly known as “the pill”) have made them the most popular form of birth control in the United States. However, concerns have been raised […]
Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study*
Dr Victor Moreno MD F Xavier Bosch MD, Nubia Muñoz MD, ProfChris JLM Meijer MD, Prof Keerti V Shah MD, Jan MM Walboomers PhD, Rolando Herrero MD, Silvia Franceschi MD, and for the International Agency for Research on Cancer (IARC) Multicentric Cervical Cancer Study Group Summary Background Use of oral contraceptives could increase risk of […]
Cross-Neutralization Potential of Native Human Papillomavirus N-Terminal L2 Epitopes
Michael J. Conway, Linda Cruz, Samina Alam, Neil David Christensen, Craig Meyers Background: Human papillomavirus (HPV) capsids are composed of 72 pentamers of the major capsid protein L1, and an unknown number of L2 minor capsid proteins. An N-terminal “external loop” of L2 contains cross-neutralizing epitopes, and native HPV16 virions extracted from 20-day-old organotypic tissues […]
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