Kreuter J. Institut für Pharmazeutische Technologie, Biozentrum, J.W.Goethe-Universität, D-60439 Frankfurt, Germany. kreuter@em.uni-frankfurt.de Abstract The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to […]
Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.
Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, Von Briesen H. Eur J Neurosci. 2000 Jun;12(6):1931-40. Abstract Certain drugs such as dalargin, loperamide or tubocurarine are not transported across the blood-brain barrier (BBB) and therefore exhibit no effects on the central nervous system. However, effects on the central nervous system can […]
DELAYED EFFECTS OF NEONATAL EXPOSURE TO TWEEN 80 ON FEMALE REPRODUCTIVE ORGANS IN RATS
M. GAJDOV, J. JAKUBOVSKY, and J. VALKY *Institute of Preventive and Clinical Medicine, Limbov~i 14, 833 01 Bratislava, lnstitute of Pathologic Anatomy, Medical Faculty, Comenium University, and :~Clinic of Gynaecology and Obstetrics, Teaching Hospital, Bratislava, Czechoslovakia (Accepted 23 October 1992) Abstract–Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or […]
Vaccine Package Inserts
If you are looking for additional information on any FDA approved vaccine, this is the perfect site. Package inserts are available for every vaccine approved for use in the United States. Typically, package inserts will explain what the vaccine is used for, what ingredients are contained in the vaccine, and a list of potential side […]
Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle
Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Itrracytoplasmic inclusions have been observed in macrophages of some patients….. We conclude that the MMF lesion is secondary to intramuscular injection of aluminum hydroxide-containing […]