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Nanoparticulate systems for brain delivery of drugs.

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Kreuter J. Institut für Pharmazeutische Technologie, Biozentrum, J.W.Goethe-Universität, D-60439 Frankfurt, Germany. kreuter@em.uni-frankfurt.de Abstract The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to […]

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Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.

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Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, Von Briesen H. Eur J Neurosci. 2000 Jun;12(6):1931-40. Abstract Certain drugs such as dalargin, loperamide or tubocurarine are not transported across the blood-brain barrier (BBB) and therefore exhibit no effects on the central nervous system. However, effects on the central nervous system can […]

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Nano-sized Vaccines

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MIT engineers have designed a new type of nanoparticle that could safely and effectively deliver vaccines for diseases such as HIV and malaria. The new particles, described in the Feb. 20 issue of Nature Materials, consist of concentric fatty spheres that can carry synthetic versions of proteins normally produced by viruses. These synthetic particles elicit […]

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Virus-mimic 'paves way for vaccine'

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From The Press Association Artificial particles which resemble virus material could form the basis of super-efficient vaccines, new research has suggested. The nanoparticles have already been used to protect mice and monkeys against flu. Scientists now hope to develop hybrid natural-synthetic vaccines that can prevent serious infections for a lifetime. The experimental vaccine consists of […]

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