Nature Medicine (2011)doi:10.1038/nm.2403 Received: 11 February 2011 Accepted: 19 May 2011 Published online: 17 July 2011 Abstract Aluminum-based adjuvants (aluminum salts or alum) are widely used in human vaccination, although their mechanisms of action are poorly understood. Here we report that, in mice, alum causes cell death and the subsequent release of host cell […]