Amy S. McKeea,b, Matthew A. Burchillb, Michael W. Munksb, Lei Jinc, John W. Kapplerb,c,d,Rachel S. Friedmanc, Jordan Jacobellic, and Philippa Marrackb,c,e,1 Significance Alum has been used to improve the efficacy of vaccines since the 1930s. Here we show that alum acts in part via host DNA to increase the interaction time between T cells and APCs. Abstract Many vaccines include […]
DNA released from dying host cells mediates aluminum adjuvant activity
Nature Medicine (2011)doi:10.1038/nm.2403 Received: 11 February 2011 Accepted: 19 May 2011 Published online: 17 July 2011 Abstract Aluminum-based adjuvants (aluminum salts or alum) are widely used in human vaccination, although their mechanisms of action are poorly understood. Here we report that, in mice, alum causes cell death and the subsequent release of host cell […]
