Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations Matthew Mold,1 Emma Shardlow,1 and Christopher Exleya,1 Author information ► Article notes ► Copyright and License information ► Abstract Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) […]
Biopersistence and brain translocation of aluminum adjuvants of vaccines
Authors: Romain Kroum Gherardi*, Housam Eidi, Guillemette Crépeaux, François Jerome Authier and Josette Cadusseau Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic […]
Behavioral abnormalities in young female mice
Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. Authors: Inbar R1, Weiss R2, Tomljenovic L3, Arango MT4, Deri Y5, Shaw CA6, Chapman J7, Blank M5, Shoenfeld Y8 Abstract Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine […]
France discusses the aluminum adjuvants safety
Aluminum Adjuvants Safety [SaneVax: Research scientists from around the world gathered in France to present their concerns regarding the role aluminum adjuvants can play in the onset of neurological disorders in May 2014. Watch Didier Lambert, President of the Association E3M, discussing the two vaccine safety conferences. Video is in French with English subtitles.] Le 22 […]
Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line
Intracellular Aluminium Adjuvant Authors: Matthew Mold, Håkan Eriksson, Peter Siesjö, Anna Darabi, Emma Shardlow & Christopher Exley Abstract Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological activities of ABA several studies have identified shape, crystallinity and size as critical factors affecting their adjuvanticity. In […]
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