Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

February 21, 2016 By

Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]




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Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

July 30, 2015 By

Authors: Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]




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WWII Military Handbook Reveals Pesticide Chemicals Used In Infant Vaccines

September 10, 2011 By 4 Comments

Vaccine Truth By Jeffry John Aufderheide | September 10th, 2011 A United States military handbook published in 1946 shows chemical compounds used in formulating the pesticide DDT are currently injected into babies. The handbook entitled, “DDT and Other Insecticides and Repellents”, reveals Triton X-100, Tween 20, and Tween 80 were used as major components of […]




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Filed Under: Environmental Health, Heavy Metal Toxicity, Immunization Practices, Vaccine Ingredient Research Tagged With: , , , ,

Jab that could put a stop to stress without slowing us down

July 31, 2011 By Leave a Comment

Mail Online By Rachel Quigley Last updated at 10:32 AM on 2nd August 2010 Forget the age-old remedies of yoga, meditation or popping pills. Relieving chronic stress could soon be as simple as having an injection, according to scientists. Academics say they are close to developing the first vaccine for stress – a single jab […]




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Filed Under: Neurology, Science & Medicine, Vaccine Ingredient Research, Vaccine Related Research Tagged With: , , , ,

Estrogens regulate neuroinflammatory genes via estrogen receptors alpha and beta in the frontal cortex of middle-aged female rats

July 27, 2011 By Leave a Comment

7th Space Interactive July 23, 2011 Estrogens exert anti-inflammatory and neuroprotective effects in the brain mainly via estrogen receptors alpha (ERalpha) and beta (ERbeta). These receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors. This study was aimed at the elucidation of the effects of ERalpha and ERbeta agonists on the expression […]




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Filed Under: Science & Medicine, Vaccine Ingredient Research, Vaccine Related Research Tagged With: , , ,

SmartVax: Weigh The Risks

July 27, 2011 By Leave a Comment

Age of Autism By Scott Laster, SafeMinds July 26, 2011 SafeMinds has launched a new website, SmartVax, to change the discourse on vaccines in a manner that will create a positive environment where consumers are empowered and scientists are encouraged to pursue the necessary research on vaccine-injury and vaccine-effectiveness.  The website raises an important question: […]




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Filed Under: Vaccine Ingredient Research, Vaccine Injuries, Vaccine Safety, Vaccines and the Media Tagged With: , , , ,

The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats

June 23, 2011 By

Barbro C. Carlson,* Åsa M. Jansson,* Anders Larsson,† Anders Bucht,‡* and Johnny C. Lorentzen* From the Department of Medicine,* Unit of Rheumatology, Karolinska Institutet, Stockholm; the Department of Medical Sciences,† University Hospital, Uppsala; and the Department of Biomedicine,‡ Division of NBC Defense, Defense Research Establishment, Umeå, Sweden Accepted February 9, 2000. Abstract: Squalene is a cholesterol […]




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Filed Under: Squalene

Nanoparticulate systems for brain delivery of drugs.

March 15, 2011 By

Kreuter J. Institut für Pharmazeutische Technologie, Biozentrum, J.W.Goethe-Universität, D-60439 Frankfurt, Germany. kreuter@em.uni-frankfurt.de Abstract The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to […]




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Filed Under: Polysorbates Tagged With: ,

Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.

March 15, 2011 By

Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, Von Briesen H. Eur J Neurosci. 2000 Jun;12(6):1931-40. Abstract Certain drugs such as dalargin, loperamide or tubocurarine are not transported across the blood-brain barrier (BBB) and therefore exhibit no effects on the central nervous system. However, effects on the central nervous system can […]




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DELAYED EFFECTS OF NEONATAL EXPOSURE TO TWEEN 80 ON FEMALE REPRODUCTIVE ORGANS IN RATS

February 2, 2011 By

M. GAJDOV, J. JAKUBOVSKY, and J. VALKY  *Institute of Preventive and Clinical Medicine, Limbov~i 14, 833 01 Bratislava, lnstitute of Pathologic Anatomy, Medical Faculty, Comenium University, and :~Clinic of Gynaecology and Obstetrics, Teaching Hospital, Bratislava, Czechoslovakia (Accepted 23 October 1992) Abstract–Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or […]




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Vaccine Package Inserts

January 25, 2011 By

If you are looking for additional information on any FDA approved vaccine, this is the perfect site. Package inserts are available for every vaccine approved for use in the United States. Typically, package inserts will explain what the vaccine is used for, what ingredients are contained in the vaccine, and a list of potential side […]




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Filed Under: Vaccine Ingredient Research Tagged With: ,

Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle

January 16, 2011 By

Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Itrracytoplasmic inclusions have been observed in macrophages of some patients….. We conclude that the MMF lesion is secondary to intramuscular injection of aluminum hydroxide-containing […]




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Filed Under: Vaccine Adjuvants, Vaccine Ingredient Research Tagged With: , , ,

Aluminum adjuvant linked to Gulf War Illness induces motor neuron death in mice

January 16, 2011 By

Michael S. Petrik, Margaret C. Wong, Rena C. Tabata, Robert F. Garry and Christopher A. Shaw Abstract Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many […]




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Filed Under: Vaccine Adjuvants, Vaccine Ingredient Research Tagged With: , , , , , , , , ,

New-Age Vaccine Adjuvants: Friend or Foe?

January 16, 2011 By

By:  Nikolai Petrovsky, Susanne Heinzel, Yoshikazu Honda, and A. Bruce Lyons A major unsolved challenge in development is how to achieve a potent adjuvant effect while avoiding reactogenicity or toxicity. Older vaccines made from live or killed whole organisms were effective, but suffered from high reactogenicity. As vaccine manufacturers developed safer, less reactogenic subunit vaccines, […]




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Vaccine Excipients and Media Summary

January 16, 2011 By

Excipients are inactive ingredients of a drug product necessary for production of a finished pharmaceutical formulation. Growth media are culture materials used to produce mass quantities of micro-organism antibodym, or other immunologic agent, suitable for further processing into a pharmaceutical. Below is a summary of the excipients and culture media included in most vaccines licensed […]




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Vaccine Hypersensitivity – Update and Overview

January 16, 2011 By

By:  Philipp J. Fritsche, et al. Summary  Concerns about possible reactions to vaccines or vaccinations are frequently raised.  However, the rate of reported vaccine-induced adverse events is low and ranges between 4.8–83.0 per 100 000 doses of the most frequently used vaccines. The number of true allergic reactions to routine vaccines is not known; estimations […]




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Filed Under: Immunization Practices, Vaccine Ingredient Research Tagged With: , , , , ,

Aluminum Hydroxide Injections Lead to Motor Deficits and Motor Neuron Degeneration

January 16, 2011 By

Authors:  Christopher Shaw/Michael Petrik 10 Feb 2010 Abstract:  Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990–1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except […]




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Filed Under: Immunization Practices, Vaccine Adjuvants, Vaccine Ingredient Research Tagged With: , , , , , , , , , ,

Synoptic Overview: Issues in Immunization Theory and Practice

January 16, 2011 By

Prepared by:  Raymond Obamsowin November 2009 IMMUNIZATION THEORY ISSUES: Theory: Vaccination is the injection of antigenic material, such as pathogen derived foreigh proteins and toxic adjuvants into the body, to initiate a “learned” immune system response in order to prevent particular diseases. Memory T cells (cell-mediated immunity) and Memory B cells (humoral-mediated immunity) learn to […]




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Filed Under: Immunization Practices, Vaccine Adjuvants, Vaccine Ingredient Research Tagged With: , , , ,