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Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

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Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]

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Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

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Authors: Coors EA1, Seybold H, Merk HF, Mahler V. Abstract BACKGROUND: Polyoxyethylene-sorbitan-20-monooleate (also known as polysorbate 80 and Tween 80) is a solubilizing agent ubiquitously used in nutritives, creams, ointments, lotions, and multiple medical preparations (e.g., vitamin oils, vaccines, and anticancer agents) and as an additive in tablets. Whereas its relevance as a contact allergen has […]

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WWII Military Handbook Reveals Pesticide Chemicals Used In Infant Vaccines

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Vaccine Truth By Jeffry John Aufderheide | September 10th, 2011 A United States military handbook published in 1946 shows chemical compounds used in formulating the pesticide DDT are currently injected into babies. The handbook entitled, “DDT and Other Insecticides and Repellents”, reveals Triton X-100, Tween 20, and Tween 80 were used as major components of […]

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Estrogens regulate neuroinflammatory genes via estrogen receptors alpha and beta in the frontal cortex of middle-aged female rats

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7th Space Interactive July 23, 2011 Estrogens exert anti-inflammatory and neuroprotective effects in the brain mainly via estrogen receptors alpha (ERalpha) and beta (ERbeta). These receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors. This study was aimed at the elucidation of the effects of ERalpha and ERbeta agonists on the expression […]

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SmartVax: Weigh The Risks

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Age of Autism By Scott Laster, SafeMinds July 26, 2011 SafeMinds has launched a new website, SmartVax, to change the discourse on vaccines in a manner that will create a positive environment where consumers are empowered and scientists are encouraged to pursue the necessary research on vaccine-injury and vaccine-effectiveness.  The website raises an important question: […]

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The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats

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Barbro C. Carlson,* Åsa M. Jansson,* Anders Larsson,† Anders Bucht,‡* and Johnny C. Lorentzen* From the Department of Medicine,* Unit of Rheumatology, Karolinska Institutet, Stockholm; the Department of Medical Sciences,† University Hospital, Uppsala; and the Department of Biomedicine,‡ Division of NBC Defense, Defense Research Establishment, Umeå, Sweden Accepted February 9, 2000. Abstract: Squalene is a cholesterol […]

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Nanoparticulate systems for brain delivery of drugs.

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Kreuter J. Institut für Pharmazeutische Technologie, Biozentrum, J.W.Goethe-Universität, D-60439 Frankfurt, Germany. kreuter@em.uni-frankfurt.de Abstract The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to […]

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Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.

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Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, Von Briesen H. Eur J Neurosci. 2000 Jun;12(6):1931-40. Abstract Certain drugs such as dalargin, loperamide or tubocurarine are not transported across the blood-brain barrier (BBB) and therefore exhibit no effects on the central nervous system. However, effects on the central nervous system can […]

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DELAYED EFFECTS OF NEONATAL EXPOSURE TO TWEEN 80 ON FEMALE REPRODUCTIVE ORGANS IN RATS

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M. GAJDOV, J. JAKUBOVSKY, and J. VALKY  *Institute of Preventive and Clinical Medicine, Limbov~i 14, 833 01 Bratislava, lnstitute of Pathologic Anatomy, Medical Faculty, Comenium University, and :~Clinic of Gynaecology and Obstetrics, Teaching Hospital, Bratislava, Czechoslovakia (Accepted 23 October 1992) Abstract–Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or […]

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Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle

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Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Itrracytoplasmic inclusions have been observed in macrophages of some patients….. We conclude that the MMF lesion is secondary to intramuscular injection of aluminum hydroxide-containing […]

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Aluminum adjuvant linked to Gulf War Illness induces motor neuron death in mice

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Michael S. Petrik, Margaret C. Wong, Rena C. Tabata, Robert F. Garry and Christopher A. Shaw Abstract Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many […]

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New-Age Vaccine Adjuvants: Friend or Foe?

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By:  Nikolai Petrovsky, Susanne Heinzel, Yoshikazu Honda, and A. Bruce Lyons A major unsolved challenge in development is how to achieve a potent adjuvant effect while avoiding reactogenicity or toxicity. Older vaccines made from live or killed whole organisms were effective, but suffered from high reactogenicity. As vaccine manufacturers developed safer, less reactogenic subunit vaccines, […]

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Vaccine Excipients and Media Summary

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Excipients are inactive ingredients of a drug product necessary for production of a finished pharmaceutical formulation. Growth media are culture materials used to produce mass quantities of micro-organism antibodym, or other immunologic agent, suitable for further processing into a pharmaceutical. Below is a summary of the excipients and culture media included in most vaccines licensed […]

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Vaccine Hypersensitivity – Update and Overview

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By:  Philipp J. Fritsche, et al. Summary  Concerns about possible reactions to vaccines or vaccinations are frequently raised.  However, the rate of reported vaccine-induced adverse events is low and ranges between 4.8–83.0 per 100 000 doses of the most frequently used vaccines. The number of true allergic reactions to routine vaccines is not known; estimations […]

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Aluminum Hydroxide Injections Lead to Motor Deficits and Motor Neuron Degeneration

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Authors:  Christopher Shaw/Michael Petrik 10 Feb 2010 Abstract:  Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990–1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except […]

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Synoptic Overview: Issues in Immunization Theory and Practice

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Prepared by:  Raymond Obamsowin November 2009 IMMUNIZATION THEORY ISSUES: Theory: Vaccination is the injection of antigenic material, such as pathogen derived foreigh proteins and toxic adjuvants into the body, to initiate a “learned” immune system response in order to prevent particular diseases. Memory T cells (cell-mediated immunity) and Memory B cells (humoral-mediated immunity) learn to […]

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