Pub Med Central
Clin Perinatol. Author manuscript; available in PMC 2010 December 1.
Published in final edited form as:
Clin Perinatol. 2009 December; 36(4): 859–880.
Fernando F. Gonzalez, M.D.a and Donna M. Ferriero, M.D.ab
Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells.