John R. Johnson, Yang-Min Ning, Ann Farrell, Robert Justice, Patricia Keegan and Richard Pazdur Abstract We reviewed the regulatory history of the accelerated approval process and the US Food and Drug Administration (FDA) experience with accelerated approval of oncology products from its initiation in December 11, 1992, to July 1, 2010. The accelerated approval regulations […]
High-Risk and Multiple Human Papillomavirus Infections Associated with Cervical Abnormalities in Japanese Women
Toshiyuki Sasagawa, Walid Basha, Hiroshi Yamazaki, and Masaki Inoue Abstract To estimate the risk of human papillomavirus (HPV) infection for cervical malignancies, we conducted a case-control study in Japan. Abnormal cervical cell (366) and normal cell samples (1562) were tested for the presence of HPV DNA using a new PCR-based test (LCR-E7 PCR). When single […]
Human papillomavirus (HPV) type distribution in cervical carcinoma, low-grade, and high-grade squamous intraepithelial lesions in Venezuelan women.
Correnti M, Medina F, Cavazza ME, Rennola A, Avila M, Fernándes A. Abstract OBJECTIVE: Cervical cancer is an important cause of mortality among women in developing countries, especially in the Latin America and Caribbean (LAC) region. Infection with high-risk (HR) human papillomavirus (HPV) has been identified as the primary cause of cervical cancer. The aim […]
Impact of Improved Classification on the Association of Human Papillomavirus
Philip E. Castle*, Mark Schiffman, Cosette M. Wheeler, Nicolas Wentzensen, and Patti E. Gravitt Initially submitted June 1, 2009; accepted for publication August 5, 2009. Correspondence to Dr. Philip E. Castle, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, MSC 7234, Bethesda, MD 20892-7234 (e-mail: castlep@mail.nih.gov). Misclassification of exposure […]
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer
Chatterjee K, Williamson AL, Hoffman M, Dandara C. Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine (IIDMM), University of Cape Town, Cape Town, Republic of South Africa. Abstract Only a small fraction of women infected with human papillomavirus (HPV) progress to cervical cancer pointing to additional risk factors including host genetics […]