Kreuter J. Institut für Pharmazeutische Technologie, Biozentrum, J.W.Goethe-Universität, D-60439 Frankfurt, Germany. kreuter@em.uni-frankfurt.de Abstract The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to […]
Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.
Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, Von Briesen H. Eur J Neurosci. 2000 Jun;12(6):1931-40. Abstract Certain drugs such as dalargin, loperamide or tubocurarine are not transported across the blood-brain barrier (BBB) and therefore exhibit no effects on the central nervous system. However, effects on the central nervous system can […]
MIT tests new nanoparticle for vaccine delivery
By Ryan McBride While there’s been some progress to make synthetic vaccines for HIV that avoid the dangers of using the virus itself to spur the body’s defenses, delivering the synthetic vaccines with existing technology hasn’t elicited the desired immune responses. MIT researchers might have found one way to overcome this delivery challenge—a new nanoparticle […]
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer
Chatterjee K, Williamson AL, Hoffman M, Dandara C. Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine (IIDMM), University of Cape Town, Cape Town, Republic of South Africa. Abstract Only a small fraction of women infected with human papillomavirus (HPV) progress to cervical cancer pointing to additional risk factors including host genetics […]
Evaluation of type-specific HPV persistence and high-risk HPV viral load quantitation in HPV positive women under 30 with normal cervical cytology.
Carcopino X, Bolger N, Henry M, Mancini J, Boubli L, Olive D, Cleary S, Prendiville W, Tamalet C. Abstract The persistence of high-risk HPV (HR-HPV) infection is necessary for the development of cervical intraepithelial neoplasia. The aim of this study was to evaluate if HR-HPV typing and HPV16, 18, 31, and 33 quantitation are predictive […]
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