A Randomized Trial JAMA. 2007;298:743-753. Main Outcome Measures Presence of HPV DNA was determined in cervical specimins by a molecular hybridization assay using chemiluminescence with HPV RNA probes and by polymerase chain reaction using SPF10 primers and a line probe assay detection system before vaccination and by polymerase chain reaction after vaccination. We compared rates of […]
GARDASIL: Prophylactic Human Papillomavirus Vaccine Development – From Bench Top to Bed-side
L Shi1, HL Sings1, JT Bryan1, B Wang1, Y Wang1, H Mach1, M Kosinski1, MW Washabaugh1, R Sitrin1 and E Barr1 February 2007 GARDASILs (Merck, Whitehouse Station, NJ) is a non-infectious recombinant, quadrivalent vaccine prepared from the highly purified virus-like particles (VLPs) of the major capsid proteins of human papillomavirus (HPV) types 6, 11, […]
Gardasil: from bench, to bedside, to blunder
The Lancet, Volume 375, Issue 9719 , Pages 963 – 964, 20 March 2010 By: Peter S. Bach The 2006 approval of Merck’s human papillomavirus (HPV) vaccine (Gardasil) by the US Food and Drug Administration (FDA) exemplified the potential of bench-to-bedside research. This vaccine against the virus that causes cervical cancer received immediate recommendation […]
Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients
This study is currently recruiting participants. Verified by University of Alberta, February 2010 Official Title Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients Purpose Human papillomavirus (HPV) affects a significant number of transplant patients. In women, human papillomavirus (HPV) causes genital warts, pre-cancerous areas of the cervix, and cervical cancer. […]
Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India
This study has been suspended. (Temporarily suspended: waiting for Indian Governement clearance ) Official Title Randomised Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India Purpose The primary study hypothesis is that a two-dose human papillomavirus (HPV) vaccine regimen would offer similar immunogenicity and protection as that of a three-dose regimen […]