“Intramuscular injection of alum-containing vaccine was associated with the appearance of aluminum deposits in distant organs, such as spleen and brain where they were still detected one year after injection.” How does this happen? What are the potential risks? Read the study below: Slow CCL2-dependent translocation of biopersistent particles from muscle to brain Zakir Khan1,2, Christophe […]
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells
Amy S. McKeea,b, Matthew A. Burchillb, Michael W. Munksb, Lei Jinc, John W. Kapplerb,c,d,Rachel S. Friedmanc, Jordan Jacobellic, and Philippa Marrackb,c,e,1 Significance Alum has been used to improve the efficacy of vaccines since the 1930s. Here we show that alum acts in part via host DNA to increase the interaction time between T cells and APCs. Abstract Many vaccines include […]
Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
Lucija Tomljenovic a,⁎, Christopher A. Shaw a,b a Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W. 10th Ave, Vancouver, BC, Canada V5Z 1L8 b Departments of Ophthalmology and Visual Sciences and Experimental Medicine and the Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, 828 […]
DNA released from dying host cells mediates aluminum adjuvant activity
Nature Medicine (2011)doi:10.1038/nm.2403 Received: 11 February 2011 Accepted: 19 May 2011 Published online: 17 July 2011 Abstract Aluminum-based adjuvants (aluminum salts or alum) are widely used in human vaccination, although their mechanisms of action are poorly understood. Here we report that, in mice, alum causes cell death and the subsequent release of host cell […]
Aluminum Vaccine Adjuvants: Are They Safe?
L. Tomljenovic*,1 and C.A. Shaw2 1Post-doctoral fellow, Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada 2Professor, Departments of Ophthalmology and Visual Sciences and Experimental Medicine and the Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, 828 W. […]
